DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-9 and tlr13

DIOPT Version :9

Sequence 1:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster
Sequence 2:	XP_002935047.2	Gene:	tlr13 / 100485164	XenbaseID:	XB-GENE-5873547	Length:	948	Species:	Xenopus tropicalis

Alignment Length:	984	Identity:	234/984 - (23%)
Similarity:	378/984 - (38%)	Gaps:	276/984 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SIQDGLIIEPDSATTSSEEAEEVSKERTDLKSLMLKYESDDGNSCLLDLIKDEVIWWQF----PN 88
            ::.|.||::.......|.:..::    ||||.|.           :.||..:.:...|.    |.
Frog   106 NLNDLLILDLSYNLIQSLDTVDL----TDLKHLQ-----------IFDLSHNRIHTIQMGTLGPL 155

  Fly    89 GTLRDSTKKYAHKLYLDLSHGNLKDDSDLFREA--KLSRKVTIWRTEVFSAAFNTLTAAPFRTLY 151
            |.|::          ||||..|:.|    ||..  .:|:.....|   .|.:.|.:|........
Frog   156 GALQE----------LDLSFNNVSD----FRSVANAVSQLPDFLR---LSLSSNFITDLKSEQSV 203

  Fly   152 SMRESLKLLSLRGNNFAELIPDAEDFARFVNESRLEASNSVPHHCELLLLHNTTDLYDRECYLYF 216
            ::..||:.|:||.|:.:.|     ||..:          |:|...||.:..|.....::..:
Frog   204 TVLSSLQSLNLRNNSISVL-----DFTFY----------SMPSLIELNVTRNNLSAVNKSSF--- 250

  Fly   217 NNNTNMGQSITTGRNYTNFIK----VLKDRFDQHGSS----------SQSIAWATFPK------- 260
             :|..|...:|...|..|..:    ||.:..:.|.||          |....:.||||
Frog   251 -SNLPMLAKVTFDENSLNISQLLGLVLPNLTEFHWSSMRPALQHELVSACQVFQTFPKLQLLDIK 314

  Fly   261 ---------------------------MPRLVELDISN-----------CSIEYVSKEAFRNVSN 287
                                       :|||.|.|:.:           |.:..::..::|.::|
Frog   315 HSKIAVTNLSIIGRCTNLTSLILSTSPLPRLQEKDLQDFKYLEVLYLDKCKLRRIANSSWRGLNN 379

  Fly   288 LRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQLPTLEMALSLIYGLKIQQNVFK 352
            |..|.:..|::..:....|..:..:|||||| .|:||:                    :.:..|.
Frog   380 LHTLILERNQLSDLEDKLFSPLTSLQYLDLS-KNYLTH--------------------LNEKAFS 423

  Fly   353 YLPELIYLDLSHSKM---TRNSAVAFAHLGDKLKFLSLCYTAIPMVSST--IFKNTVLEGLDLSG 412
            .|..|.||.|...|:   |||:...|::    |:.|.|...:|.::.|.  |:... ||.|.|||
Frog   424 GLRRLNYLSLKGCKITAATRNNFRYFSN----LRVLDLQDNSISLIKSNAHIYLRK-LETLLLSG 483

  Fly   413 NPYLSYNIIDDAFDGIANTLKYLYFERSNIKDL--EWSKSLKNLQVLGLAGNNINAL----TPAM 471
            |..|:  |..:...|:. :||.|....:||..:  ...|.:|:|:.|.|:.|.:..|    :|..
Frog   484 NKILT--IQKNGLKGLV-SLKELSLANNNIYKITDNTFKFVKSLRSLDLSRNQLWPLHKFQSPTP 545

  Fly   472 FQSLESLEILDLSSNHVGNWY--RSAFHNNSALRVLNLRSNTINMLSN---EMLKDFERLDYLSL 531
            |.:|..||.||.|....||.|  .|.|....:|:||.|:.|......|   |.|.:...||
Frog   546 FLNLTQLEYLDASYQAEGNIYIPASLFQGLQSLKVLRLQGNPSAFFRNVSFEFLLNLTELD---- 606

  Fly   532 GDNDFICDCHLRAVVEVAAANNKDADCSYRLLNYSQNAVGEEVISLAESLIIDRKLWQSR----- 591
                      :.|.|                  |:..   :..||..:.|.  :||.|.|
Frog   607 ----------ISATV------------------YTMT---DPPISFEKELF--KKLGQLRNLTLD 638

  Fly   592 -----YIPWLQRSYSNI-------REFNRANHIIKLRFSSED-------------YM-VAKCSAA 630
                 ::|  :..::|:       ..:||..:|      |||             || ...||..
Frog   639 NNGIQFLP--EDVFTNVPMLEHISLRYNRLTNI------SEDILKNVPNLNYFDMYMNTLSCSCD 695

  Fly   631 QPY--HLGDLDGDLTLKFQLLDYEASQYYCFNNTDQLQVDELNCQIRSMSDLAEELHHVTNT-VI 692
            ..:  :....:.::.:.|      ...|.||.    |:.:|:..:.:..|       ..||| ..
Frog   696 NYWFQNWSKCNTEVQIPF------IQSYKCFG----LEANEMLFENQDFS-------FCTNTGYY 743

  Fly   693 AVMGSLV---GACILGFIIYLKRWHIHYYYSSLKSAALLSSASKESVNKFTNISQRDPSAVYDIF 754
            ..:||.:   ....:..::...:|.:.|.|..|:........:.:.|:|            ||.:
Frog   744 FFLGSFIITFSLLTVNLLVVKLKWTVRYMYCMLEVWFRWKLETTDKVHK------------YDAY 796

  Fly   755 ISYCQNDRTWVLNELLPNVEETGD--VSICLHERDFQIGVTILDNIISCMDRSYSLMLIISSKFL 817
            ||||::|..||:.:||..:||.|.  ..:|...|||..|:..||||...:..|...:.::|.|:|
Frog   797 ISYCEDDEIWVVEKLLHMLEEQGQRKFKLCFKPRDFVPGIYHLDNIQDAISNSRKTLCVVSRKYL 861

  Fly   818 LSHWCQFEMYLAQHRIFEVSKEHLILVFLEDIP--RRKRPKTLQYLMDVKTYIKWPTAKEDRKLF 880
            .|.||:.||.||....|...::.|::||||:||  |......|:.|:...|||.||......::|
Frog   862 ESEWCREEMQLACSWAFSYKEDVLLMVFLEEIPEYRLSAYHKLRKLIKQNTYIDWPEDPRGEEVF 926

  Fly   881 WKRLKRSLE 889
            |.:|:::|:
Frog   927 WLKLRQALD 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	8/27 (30%)
		LRR_8	262..322	CDD:290566	18/70 (26%)
		leucine-rich repeat	264..287	CDD:275380	5/33 (15%)
		leucine-rich repeat	288..311	CDD:275380	4/22 (18%)
		leucine-rich repeat	312..356	CDD:275380	11/43 (26%)
		LRR_8	<344..387	CDD:290566	13/45 (29%)
		leucine-rich repeat	357..381	CDD:275380	9/26 (35%)
		leucine-rich repeat	382..397	CDD:275380	4/14 (29%)
		leucine-rich repeat	405..430	CDD:275380	10/24 (42%)
		LRR_8	431..488	CDD:290566	20/62 (32%)
		leucine-rich repeat	432..453	CDD:275380	6/22 (27%)
		LRR_RI	<449..536	CDD:238064	30/95 (32%)
		leucine-rich repeat	454..477	CDD:275380	8/26 (31%)
		LRR_8	477..536	CDD:290566	20/63 (32%)
		leucine-rich repeat	478..501	CDD:275380	10/24 (42%)
		leucine-rich repeat	502..525	CDD:275380	8/25 (32%)
		TIR	751..891	CDD:214587	54/143 (38%)
tlr13	XP_002935047.2	LRR_RI	<29..220	CDD:238064	34/145 (23%)
		leucine-rich repeat	62..85	CDD:275380
		LRR_8	63..144	CDD:290566	11/52 (21%)
		leucine-rich repeat	86..133	CDD:275380	7/30 (23%)
		LRR_8	132..192	CDD:290566	19/87 (22%)
		leucine-rich repeat	134..157	CDD:275380	5/33 (15%)
		leucine-rich repeat	158..208	CDD:275380	14/66 (21%)
		LRR_8	186..242	CDD:290566	18/73 (25%)
		leucine-rich repeat	209..231	CDD:275380	9/36 (25%)
		leucine-rich repeat	232..307	CDD:275380	16/78 (21%)
		LRR_RI	253..534	CDD:238064	73/309 (24%)
		leucine-rich repeat	308..331	CDD:275380	0/22 (0%)
		leucine-rich repeat	332..355	CDD:275380	5/22 (23%)
		leucine-rich repeat	356..379	CDD:275380	2/22 (9%)
		LRR_8	379..438	CDD:290566	20/79 (25%)
		leucine-rich repeat	380..403	CDD:275380	4/22 (18%)
		leucine-rich repeat	404..427	CDD:275380	11/43 (26%)
		leucine-rich repeat	428..451	CDD:275380	9/22 (41%)
		leucine-rich repeat	452..475	CDD:275380	6/22 (27%)
		LRR_8	474..534	CDD:290566	21/63 (33%)
		leucine-rich repeat	476..499	CDD:275380	10/25 (40%)
		LRR_8	499..587	CDD:290566	29/87 (33%)
		leucine-rich repeat	500..523	CDD:275380	6/22 (27%)
		leucine-rich repeat	524..577	CDD:275380	18/52 (35%)
		leucine-rich repeat	578..631	CDD:275380	18/89 (20%)
		LRR_8	631..685	CDD:290566	10/61 (16%)
		leucine-rich repeat	632..655	CDD:275380	3/24 (13%)
		leucine-rich repeat	656..676	CDD:275380	6/25 (24%)
		TIR	792..935	CDD:214587	54/154 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920