DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5665 and PNLIPRP2

DIOPT Version :9

Sequence 1:	NP_001246844.1	Gene:	CG5665 / 40243	FlyBaseID:	FBgn0036977	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_005387.3	Gene:	PNLIPRP2 / 5408	HGNCID:	9157	Length:	469	Species:	Homo sapiens

Alignment Length:	293	Identity:	83/293 - (28%)
Similarity:	121/293 - (41%)	Gaps:	77/293 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 HFQYMTPCQNYSVPLLEASKLWKHSRFSKGRKVVILATGWTNTVNESSAISMISKAFMCRGDVNF 151
            :||.:|..:..::   ||      |.|...||...:..|:.:...:|....|..|.|... .||.
Human    66 NFQLITGTEPDTI---EA------SNFQLDRKTRFIIHGFLDKAEDSWPSDMCKKMFEVE-KVNC 120

  Fly   152 VIVDAADYVDTFYAWSALNTDLIGEHIGVGLTHLIELT------PLRNIHLIGGFIKESFVSINS 210
            :.||........|..:..|..::|..    ...||:..      .|.::|:|
Human   121 ICVDWRHGSRAMYTQAVQNIRVVGAE----TAFLIQALSTQLGYSLEDVHVI------------- 168

  Fly   211 GSDFFVGHSLGAHIMGTAGRTFKKLTGKLIPRITGLDPAKPCFRREKILPGLTRGDAKLVDIIHT 275
                  |||||||....|||   :|.|: :.||||||||.|||:.|.....|...||..||:|||
Human   169 ------GHSLGAHTAAEAGR---RLGGR-VGRITGLDPAGPCFQDEPEEVRLDPSDAVFVDVIHT 223

  Fly   276 N---------IGILAKRGPLGDVDFYPGGAHPIQPGC-------LT------------IGCSHTR 312
            :         .|:..|   :|.:||:|.|...: |||       :|            :.|:|.|
Human   224 DSSPIVPSLGFGMSQK---VGHLDFFPNGGKEM-PGCKKNVLSTITDIDGIWEGIGGFVSCNHLR 284

  Fly   313 AVEYFAESAYPHQEKNFMGKKCASWDELRKRDC 345
            :.||::.|..  ....|:|..|||:||.::..|
Human   285 SFEYYSSSVL--NPDGFLGYPCASYDEFQESKC 315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5665	NP_001246844.1	Abhydrolase	85..370	CDD:304388	83/293 (28%)
PNLIPRP2	NP_005387.3	Lipase	18..354	CDD:395099	83/293 (28%)
		Required for galactolipase activity. /evidence=ECO:0000269\|PubMed:26494624	93..105		2/11 (18%)
		Required for galactolipase activity. /evidence=ECO:0000269\|PubMed:26494624	257..279		1/21 (5%)
		PLAT_PL	357..469	CDD:238857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145360
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940