DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5665 and PNLIP

DIOPT Version :9

Sequence 1:	NP_001246844.1	Gene:	CG5665 / 40243	FlyBaseID:	FBgn0036977	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_000927.1	Gene:	PNLIP / 5406	HGNCID:	9155	Length:	465	Species:	Homo sapiens

Alignment Length:	350	Identity:	89/350 - (25%)
Similarity:	133/350 - (38%)	Gaps:	74/350 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 PLELASNIIDAVCSSTLFMDRI---------------PAQITP----DIRKMHFQYMTPCQNYSV 99
            ||...|.::.||....:..:|:               |..|.|    |:......|.....|...
Human     3 PLWTLSLLLGAVAGKEVCYERLGCFSDDSPWSGITERPLHILPWSPKDVNTRFLLYTNENPNNFQ 67

  Fly   100 PLLEASKLWKHSRFSKGRKVVILATGWTNTVNESSAISMISKAFMCRGDVNFVIVDAADYVDTFY 164
            .:...|.....|.|...||...:..|:.:...|:...::....|... .||.:.||......|.|
Human    68 EVAADSSSISGSNFKTNRKTRFIIHGFIDKGEENWLANVCKNLFKVE-SVNCICVDWKGGSRTGY 131

  Fly   165 AWSALNTDLIGEHIGVGLTHLIELTPLRNIHLIGGFIKESFVSINSGSDFFVGHSLGAHIMGTAG 229
            ..::.|..::|..:    .:.:|            |::.:| ..:..:...:|||||||..|.||
Human   132 TQASQNIRIVGAEV----AYFVE------------FLQSAF-GYSPSNVHVIGHSLGAHAAGEAG 179

  Fly   230 RTFKKLTGKLIPRITGLDPAKPCFRREKILPGLTRGDAKLVDIIHT-------NIGILAKRGPLG 287
            |.    |...|.||||||||:|||:....|..|...|||.||:|||       |:| ......:|
Human   180 RR----TNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLG-FGMSQVVG 239

  Fly   288 DVDFYPGGAHPIQPGCLT-------------------IGCSHTRAVEYFAESAYPHQEKNFMGKK 333
            .:||:|.|...: |||..                   ..|:|.|:.:|:.:|..  ....|.|..
Human   240 HLDFFPNGGVEM-PGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIV--NPDGFAGFP 301

  Fly   334 CASWDELRKR---DCSAGIVSPMGY 355
            |||::.....   .|.:|....||:
Human   302 CASYNVFTANKCFPCPSGGCPQMGH 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5665	NP_001246844.1	Abhydrolase	85..370	CDD:304388	79/299 (26%)
PNLIP	NP_000927.1	Lipase	17..352	CDD:278576	84/335 (25%)
PNLIP	NP_000927.1	PLAT_PL	355..465	CDD:238857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145366
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840