DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5665 and Pnliprp2

DIOPT Version :9

Sequence 1:	NP_001246844.1	Gene:	CG5665 / 40243	FlyBaseID:	FBgn0036977	Length:	395	Species:	Drosophila melanogaster
Sequence 2:	NP_035258.2	Gene:	Pnliprp2 / 18947	MGIID:	1336202	Length:	482	Species:	Mus musculus

Alignment Length:	314	Identity:	90/314 - (28%)
Similarity:	132/314 - (42%)	Gaps:	83/314 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 PAQITP------DIRKMHFQYMTPCQNYSVPLLEASKLWKHSRFSKGRKVVILATGWTNTVNESS 134
            |::|.|      |.|.:.:....| .||.:...........|.|...||...:..|:.:...|..
Mouse    54 PSKIFPWSPEDIDTRFLLYTNENP-NNYQIISATDPATINASNFQLDRKTRFIIHGFIDKGEEGW 117

  Fly   135 AISMISKAFMCRGDVNFVIVDAADYVDTFYAWSALNTDLIGEHIGVGLTHLIEL-------TPLR 192
            .:.|..|.|... .||.:.||......|.|..::.||.::|..|    ..|:::       :| .
Mouse   118 LLDMCKKMFQVE-KVNCICVDWKRGSRTEYTQASYNTRVVGAEI----AFLVQVLSTEMGYSP-E 176

  Fly   193 NIHLIGGFIKESFVSINSGSDFFVGHSLGAHIMGTAGRTFKKLTGKLIPRITGLDPAKPCFRREK 257
            |:|||                   |||||:|:.|.|||   :|.|. :.||||||||:|||:.
Mouse   177 NVHLI-------------------GHSLGSHVAGEAGR---RLEGH-VGRITGLDPAEPCFQG-- 216

  Fly   258 ILPGLTR---GDAKLVDIIHTN---------IGILAKRGPLGDVDFYPGGAHPIQPGC-----LT 305
             ||...|   .||..||:|||:         .|:..|   :|.:||:|.|...: |||     .|
Mouse   217 -LPEEVRLDPSDAMFVDVIHTDSAPIIPYLGFGMSQK---VGHLDFFPNGGKEM-PGCQKNILST 276

  Fly   306 I--------------GCSHTRAVEYFAESAYPHQEKNFMGKKCASWDELRKRDC 345
            |              .|:|.|:.:|:|.|..  ....|:|..|:|:::.:..||
Mouse   277 IVDINGIWEGTRNFAACNHLRSYKYYASSIL--NPDGFLGYPCSSYEKFQHNDC 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5665	NP_001246844.1	Abhydrolase	85..370	CDD:304388	85/299 (28%)
Pnliprp2	NP_035258.2	Lipase	31..367	CDD:278576	90/314 (29%)
		Pancreat_lipase_like	65..363	CDD:238363	87/303 (29%)
		Required for galactolipase activity. /evidence=ECO:0000250\|UniProtKB:P54317	106..118		2/11 (18%)
		Required for galactolipase activity. /evidence=ECO:0000250\|UniProtKB:P54317	270..292		2/21 (10%)
		PLAT_PL	370..482	CDD:238857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835423
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840