DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kin17 and Kin

DIOPT Version :9

Sequence 1:	NP_649212.2	Gene:	kin17 / 40242	FlyBaseID:	FBgn0024887	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_001102999.1	Gene:	Kin / 689197	RGDID:	1596107	Length:	392	Species:	Rattus norvegicus

Alignment Length:	404	Identity:	205/404 - (50%)
Similarity:	278/404 - (68%)	Gaps:	30/404 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGRAEVGTPKYLANKMKSKGLQKLRWYCQMCEKQCRDENGFKCHTMSESHQRQLLLFADNPGKFL 65
            ||:::..:||.:||::|||||||||||||||:||||||||||||.|||||||||||.::||.:|:
  Rat     1 MGKSDFLSPKAIANRIKSKGLQKLRWYCQMCQKQCRDENGFKCHCMSESHQRQLLLASENPQQFM 65

  Fly    66 HSFSKEFSDGYMELLRRRFGTKRTSANKIYQEYIAHKEHIHMNATRWLTLSDYVKWLGRTGQVIA 130
            ..||:||.:.::|||||||||||...|.:|.|||:|:||||||||:|.||:|:.|||||.|....
  Rat    66 DYFSEEFRNDFLELLRRRFGTKRVHNNIVYNEYISHREHIHMNATQWETLTDFTKWLGREGLCKV 130

  Fly   131 DETEKGWFVTYIDRSPEAMERQAKADRKEKMEKDDEERMADFIEQQIKNAKAKDGEEDEGQEKFT 195
            |||.|||::.||||.||.:.||.:.::|:|.:.||||:.|.|||:|::  :..:|:|.| ...||
  Rat   131 DETPKGWYIQYIDRDPETIRRQLELEKKKKQDLDDEEKTAKFIEEQVR--RGLEGKEQE-TPVFT 192

  Fly   196 ELKREENEPLKLDIRLEK--------KFQPDTVLGKSAL---------AKRPAPEAEEKVFKKPK 243
            ||.||.:|. |:...|.|        .....:.||.|||         .::.:.::..:..||.|
  Rat   193 ELSRENDEE-KVTFNLNKGAGSSAGATTSKSSSLGPSALKMLGSTASVRRKESSQSSAQPAKKKK 256

  Fly   244 SVAGDSQTRSVLDEIIKQEESKKERANRKDYWLHKGIVVKFISKSMGEKFFKQKAVVLDVIDRYQ 308
                    :|.||||::.||.|| |..|.|.||..||:||.|:|.:|||:.|:|.||.:|||||.
  Rat   257 --------KSALDEIMEIEEEKK-RTARTDSWLQPGIIVKIITKKLGEKYHKKKGVVKEVIDRYT 312

  Fly   309 GKIKFLETGEKLKVDQAHLETVIPALDKPVMVVNGAYRGSEALLRKLDERRYSVSVEILHGPLKG 373
            ..:|..::|::||:||.||||||||..|.|:|:||.|||:|..|..::|:.:|.::.|..|||||
  Rat   313 AVVKMTDSGDRLKLDQTHLETVIPAPGKRVLVLNGGYRGNEGTLESINEKTFSATIVIETGPLKG 377

  Fly   374 RIVDNVQYEDISKL 387
            |.::.:||||||||
  Rat   378 RRLEGIQYEDISKL 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kin17	NP_649212.2	Kin17_mid	55..177	CDD:287344	68/121 (56%)
kin17	NP_649212.2	KOW_KIN17	336..387	CDD:240519	25/50 (50%)
Kin	NP_001102999.1	ZnF_U1	25..54	CDD:197732	26/28 (93%)
		Kin17_mid	55..177	CDD:402119	68/121 (56%)
		KN17_SH3	275..327	CDD:407963	26/51 (51%)
		KOW_KIN17	338..391	CDD:240519	25/52 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353884
Domainoid	1	1.000	164	1.000	Domainoid score	I3869
eggNOG	1	0.900	-	-		E1_KOG2837
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8196
Inparanoid	1	1.050	399	1.000	Inparanoid score	I1876
OMA	1	1.010	-	-		QHG54826
OrthoDB	1	1.010	-	-		D1420569at2759
OrthoFinder	1	1.000	-	-		FOG0004270
OrthoInspector	1	1.000	-	-		oto96289
orthoMCL	1	0.900	-	-		OOG6_102520
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3008
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.670