DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5618 and GADL1

DIOPT Version :9

Sequence 1:	NP_649211.1	Gene:	CG5618 / 40241	FlyBaseID:	FBgn0036975	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_997242.2	Gene:	GADL1 / 339896	HGNCID:	27949	Length:	521	Species:	Homo sapiens

Alignment Length:	485	Identity:	233/485 - (48%)
Similarity:	332/485 - (68%)	Gaps:	23/485 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ILENVFHLLRKEDTFCVDPQKWDKQKIVPFLQPDKLKELINLKVRETENCSLAEIEELCQQVIHY 88
            |:|.|  :|:..|.         .:|:..:..|::||:|::|::|::.. ...::.|||:.||||
Human    56 IMEEV--VLKATDV---------NEKVCEWRPPEQLKQLLDLEMRDSGE-PPHKLLELCRDVIHY 108

  Fly    89 SVKTSHGRFHNQLFGQLDPFGLAGALVTEAMNGSTYTYEVAPVFSLIETEVIATICKLAGYKEGD 153
            ||||:|.||.|||:..||.:.|....:|||:|.|.|||||:|||.|:|..|:..:.:..|:||||
Human   109 SVKTNHPRFFNQLYAGLDYYSLVARFMTEALNPSVYTYEVSPVFLLVEEAVLKKMIEFIGWKEGD 173

  Fly   154 GIFAPGGSTSNMYGMVLARYKIAPEVKTSGMFGMRPLVLFTSDESHYSFVKAANWLGLGSYNCVS 218
            |||.||||.||||.|.|||||..|::|..|:.|...|:||||.|.|||..|||::||:|:.|...
Human   174 GIFNPGGSVSNMYAMNLARYKYCPDIKEKGLSGSPRLILFTSAECHYSMKKAASFLGIGTENVCF 238

  Fly   219 VRTNERGQMLLDDLEAKIAEAKARGGEPFFVNCTAGTTVLGAFDDINGAADVTERHGLWLHVDAC 283
            |.|:.||:|:.::||.::.:|:..|..||.|..|:|||||||||.::..||:.|||.|||||||.
Human   239 VETDGRGKMIPEELEKQVWQARKEGAAPFLVCATSGTTVLGAFDPLDEIADICERHSLWLHVDAS 303

  Fly   284 LGGAALLSAKNRSLIAGLERANSFSWNPHKTIGAPLQCSLFLTRESGRLLERCNSTEAHYLFQQD 348
            .||:||:|.|:|.|:.|:.||:|.:|||||.:.|.:||...|.::...||::|.|.:|.||||||
Human   304 WGGSALMSRKHRKLLHGIHRADSVAWNPHKMLMAGIQCCALLVKDKSDLLKKCYSAKASYLFQQD 368

  Fly   349 KFYDVSYDTGNKSVQCGRKIDAFKFWLMLKARGYGKYGL--MVDHAIHIARLLEGKLRQRGDRFR 411
            ||||||||||:||:||.|:.||||||:..||  .|..||  .|:.|:.::|.|..::::| :.|:
Human   369 KFYDVSYDTGDKSIQCSRRPDAFKFWMTWKA--LGTLGLEERVNRALALSRYLVDEIKKR-EGFK 430

  Fly   412 LVIPEHEYSNVCFWFIPKAMRVSSEEETPEWWSRLYTVAPKIKEQMAHSGTLMIGYSPLKAKNLG 476
            |:: |.||:|:|||:||.::|  ..||.||:|::|..|||.|||:|...|:||:||.|.:.|  .
Human   431 LLM-EPEYANICFWYIPPSLR--EMEEGPEFWAKLNLVAPAIKERMMKKGSLMLGYQPHRGK--V 490

  Fly   477 NFFRMVFTCFPILKSKELDFILDEIERLGE 506
            ||||.| ...|.:..:::||:||||:.||:
Human   491 NFFRQV-VISPQVSREDMDFLLDEIDLLGK 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5618	NP_649211.1	AAT_I	97..504	CDD:302748	206/408 (50%)
GADL1	NP_997242.2	AAT_I	77..445	CDD:302748	190/372 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3597
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	1	1.100	-	-	O	PTHR45677
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.780