DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5618 and GAD1

DIOPT Version :9

Sequence 1:	NP_649211.1	Gene:	CG5618 / 40241	FlyBaseID:	FBgn0036975	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_000808.2	Gene:	GAD1 / 2571	HGNCID:	4092	Length:	594	Species:	Homo sapiens

Alignment Length:	495	Identity:	228/495 - (46%)
Similarity:	318/495 - (64%)	Gaps:	28/495 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KILENVFHLLRKEDTFCVDPQKWDKQ-KIVPFLQPDKL---KELINLKVRETENCSLAEIEELCQ 83
            ::::.:.:.:||  ||       |:. |::.|..|.:|   .|..||::.:... ||.:|...|:
Human   119 EVVDILLNYVRK--TF-------DRSTKVLDFHHPHQLLEGMEGFNLELSDHPE-SLEQILVDCR 173

  Fly    84 QVIHYSVKTSHGRFHNQLFGQLDPFGLAGALVTEAMNGSTYTYEVAPVFSLIETEVIATICKLAG 148
            ..:.|.|:|.|.||.|||...||..||||..:|...|.:.:|||:||||.|:|...:..:.::.|
Human   174 DTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVG 238

  Fly   149 Y--KEGDGIFAPGGSTSNMYGMVLARYKIAPEVKTSGMFGMRPLVLFTSDESHYSFVKAANWLGL 211
            :  |:|||||:|||:.||||.::.||||..|||||.||..:..||||||::||||..||...||.
Human   239 WSSKDGDGIFSPGGAISNMYSIMAARYKYFPEVKTKGMAAVPKLVLFTSEQSHYSIKKAGAALGF 303

  Fly   212 GSYNCVSVRTNERGQMLLDDLEAKIAEAKARGGEPFFVNCTAGTTVLGAFDDINGAADVTERHGL 276
            |:.|.:.::.||||:::..|.||||.|||.:|..||:||.||||||.||||.|...||:.|::.|
Human   304 GTDNVILIKCNERGKIIPADFEAKILEAKQKGYVPFYVNATAGTTVYGAFDPIQEIADICEKYNL 368

  Fly   277 WLHVDACLGGAALLSAKNRSLIAGLERANSFSWNPHKTIGAPLQCSLFLTRESGRLLERCNSTEA 341
            ||||||..||..|:|.|:|..:.|:|||||.:|||||.:|..||||..|.:|.| :|:.||...|
Human   369 WLHVDAAWGGGLLMSRKHRHKLNGIERANSVTWNPHKMMGVLLQCSAILVKEKG-ILQGCNQMCA 432

  Fly   342 HYLFQQDKFYDVSYDTGNKSVQCGRKIDAFKFWLMLKARGYGKYGLMVDHAIHIARLLEGKLRQR 406
            .||||.||.||||||||:|::||||.:|.||||||.||:|...:...::..:.:|..|..|::.|
Human   433 GYLFQPDKQYDVSYDTGDKAIQCGRHVDIFKFWLMWKAKGTVGFENQINKCLELAEYLYAKIKNR 497

  Fly   407 GDRFRLVI---PEHEYSNVCFWFIPKAMRVSSEEETPEWWSRLYTVAPKIKEQMAHSGTLMIGYS 468
             :.|.:|.   |||  :|||||:||:::|  ...::|:...:|:.||||||..|..|||.|:||.
Human   498 -EEFEMVFNGEPEH--TNVCFWYIPQSLR--GVPDSPQRREKLHKVAPKIKALMMESGTTMVGYQ 557

  Fly   469 PLKAKNLGNFFRMVFTCFPILKSKELDFILDEIERLGEKI 508
            |...|  .||||||.: .|.....::||:::||||||:.:
Human   558 PQGDK--ANFFRMVIS-NPAATQSDIDFLIEEIERLGQDL 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5618	NP_649211.1	AAT_I	97..504	CDD:302748	204/411 (50%)
GAD1	NP_000808.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Pyridoxal_deC	144..518	CDD:365998	186/378 (49%)
		Substrate binding	190..192		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.730