DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5618 and Gad2

DIOPT Version :9

Sequence 1:	NP_649211.1	Gene:	CG5618 / 40241	FlyBaseID:	FBgn0036975	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_036695.1	Gene:	Gad2 / 24380	RGDID:	2653	Length:	585	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	212/490 - (43%)
Similarity:	314/490 - (64%)	Gaps:	21/490 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LENVFHLLRKEDTFCVDPQKWDKQ-KIVPFLQPDKLKELINLKVRETENCSLAEIEELCQQVIHY 88
            |::|.::|.:   :.|  :.:|:. |::.|..|::|.:..|.::.:... :|.||...||..:.|
  Rat   111 LQDVMNILLQ---YVV--KSFDRSTKVIDFHYPNELLQEYNWELADQPQ-NLEEILTHCQTTLKY 169

  Fly    89 SVKTSHGRFHNQLFGQLDPFGLAGALVTEAMNGSTYTYEVAPVFSLIETEVIATICKLAGYK--E 151
            ::||.|.|:.|||...||..|||...:|...|.:.:|||:||||.|:|...:..:.::.|:.  .
  Rat   170 AIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGS 234

  Fly   152 GDGIFAPGGSTSNMYGMVLARYKIAPEVKTSGMFGMRPLVLFTSDESHYSFVKAANWLGLGSYNC 216
            |||||:|||:.||||.|::||||:.||||..||..:..|:.|||:.||:|..|.|..||:|:.:.
  Rat   235 GDGIFSPGGAISNMYAMLIARYKMFPEVKEKGMAAVPRLIAFTSEHSHFSLKKGAAALGIGTDSV 299

  Fly   217 VSVRTNERGQMLLDDLEAKIAEAKARGGEPFFVNCTAGTTVLGAFDDINGAADVTERHGLWLHVD 281
            :.::.:|||:|:..|||.:|.|.|.:|..||.|:.||||||.||||.:...||:.:::.:|:|||
  Rat   300 ILIKCDERGKMIPSDLERRILEVKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIWMHVD 364

  Fly   282 ACLGGAALLSAKNRSLIAGLERANSFSWNPHKTIGAPLQCSLFLTRESGRLLERCNSTEAHYLFQ 346
            |..||..|:|.|::..:.|:|||||.:|||||.:|.|||||..|.||.| |::.||...|.||||
  Rat   365 AAWGGGLLMSRKHKWKLNGVERANSVTWNPHKMMGVPLQCSALLVREEG-LMQSCNQMHASYLFQ 428

  Fly   347 QDKFYDVSYDTGNKSVQCGRKIDAFKFWLMLKARGYGKYGLMVDHAIHIARLLEGKLRQRGDRFR 411
            |||.||:|||||:|::||||.:|.||.|||.:|:|...:...:|..:.:|..|...::.| :.:.
  Rat   429 QDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHIDKCLELAEYLYNIIKNR-EGYE 492

  Fly   412 LVI---PEHEYSNVCFWFIPKAMRVSSEEETPEWWSRLYTVAPKIKEQMAHSGTLMIGYSPLKAK 473
            :|.   |:|  :||||||:|.::||..:.|  |..|||..|||.||.:|...||.|:.|.||..|
  Rat   493 MVFDGKPQH--TNVCFWFVPPSLRVLEDNE--ERMSRLSKVAPVIKARMMEYGTTMVSYQPLGDK 553

  Fly   474 NLGNFFRMVFTCFPILKSKELDFILDEIERLGEKI 508
              .||||||.: .|....:::||:::||||||:.:
  Rat   554 --VNFFRMVIS-NPAATHQDIDFLIEEIERLGQDL 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5618	NP_649211.1	AAT_I	97..504	CDD:302748	189/411 (46%)
Gad2	NP_036695.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Pyridoxal_deC	138..509	CDD:278699	168/375 (45%)
		Substrate binding. /evidence=ECO:0000250	181..183		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.730