DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5618 and Gad2

DIOPT Version :9

Sequence 1:	NP_649211.1	Gene:	CG5618 / 40241	FlyBaseID:	FBgn0036975	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_032104.2	Gene:	Gad2 / 14417	MGIID:	95634	Length:	585	Species:	Mus musculus

Alignment Length:	499	Identity:	213/499 - (42%)
Similarity:	316/499 - (63%)	Gaps:	21/499 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 DGLMDDWKILENVFHLLRKEDTFCVDPQKWDKQ-KIVPFLQPDKLKELINLKVRETENCSLAEIE 79
            ||.......|::|.::|.:   :.|  :.:|:. |::.|..|::|.:..|.::.:... :|.||.
Mouse   102 DGERPTLAFLQDVMNILLQ---YVV--KSFDRSTKVIDFHYPNELLQEYNWELADQPQ-NLEEIL 160

  Fly    80 ELCQQVIHYSVKTSHGRFHNQLFGQLDPFGLAGALVTEAMNGSTYTYEVAPVFSLIETEVIATIC 144
            ..||..:.|::||.|.|:.|||...||..|||...:|...|.:.:|||:||||.|:|...:..:.
Mouse   161 THCQTTLKYAIKTGHPRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMR 225

  Fly   145 KLAGYK--EGDGIFAPGGSTSNMYGMVLARYKIAPEVKTSGMFGMRPLVLFTSDESHYSFVKAAN 207
            ::.|:.  .|||||:|||:.||||.|::||||:.||||..||..:..|:.|||:.||:|..|.|.
Mouse   226 EIIGWPGGSGDGIFSPGGAISNMYAMLIARYKMFPEVKEKGMAAVPRLIAFTSEHSHFSLKKGAA 290

  Fly   208 WLGLGSYNCVSVRTNERGQMLLDDLEAKIAEAKARGGEPFFVNCTAGTTVLGAFDDINGAADVTE 272
            .||:|:.:.:.::.:|||:|:..|||.:|.|.|.:|..||.|:.||||||.||||.:...||:.:
Mouse   291 ALGIGTDSVILIKCDERGKMIPSDLERRILEVKQKGFVPFLVSATAGTTVYGAFDPLLAVADICK 355

  Fly   273 RHGLWLHVDACLGGAALLSAKNRSLIAGLERANSFSWNPHKTIGAPLQCSLFLTRESGRLLERCN 337
            ::.:|:||||..||..|:|.|::..::|:|||||.:|||||.:|.|||||..|.||.| |::.||
Mouse   356 KYKIWMHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEG-LMQSCN 419

  Fly   338 STEAHYLFQQDKFYDVSYDTGNKSVQCGRKIDAFKFWLMLKARGYGKYGLMVDHAIHIARLLEGK 402
            ...|.|||||||.||:|||||:|::||||.:|.||.|||.:|:|...:...:|..:.:|..|...
Mouse   420 QMHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHIDKCLELAEYLYTI 484

  Fly   403 LRQRGDRFRLVI---PEHEYSNVCFWFIPKAMRVSSEEETPEWWSRLYTVAPKIKEQMAHSGTLM 464
            ::.| :.:.:|.   |:|  :||||||:|.::|...:.|  |..|||..|||.||.:|...||.|
Mouse   485 IKNR-EGYEMVFDGKPQH--TNVCFWFVPPSLRTLEDNE--ERMSRLSKVAPVIKARMMEYGTTM 544

  Fly   465 IGYSPLKAKNLGNFFRMVFTCFPILKSKELDFILDEIERLGEKI 508
            :.|.||..|  .||||||.: .|....:::||:::||||||:.:
Mouse   545 VSYQPLGDK--VNFFRMVIS-NPAATHQDIDFLIEEIERLGQDL 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5618	NP_649211.1	AAT_I	97..504	CDD:302748	188/411 (46%)
Gad2	NP_032104.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Pyridoxal_deC	138..509	CDD:278699	168/375 (45%)
		Substrate binding. /evidence=ECO:0000250	181..183		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.730