DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5618 and Ddc

DIOPT Version :9

Sequence 1:	NP_649211.1	Gene:	CG5618 / 40241	FlyBaseID:	FBgn0036975	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001177377.1	Gene:	Ddc / 13195	MGIID:	94876	Length:	480	Species:	Mus musculus

Alignment Length:	483	Identity:	120/483 - (24%)
Similarity:	199/483 - (41%)	Gaps:	95/483 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 GAETVDQIRDGLMDDWKILENVFHLLRKEDTFCVDPQKWDKQKIVPFLQPDKLKELINL---KVR 68
            |.|.||.|.|       .|:.:                 :.:.:.|.::|..|:.||..   :..
Mouse    10 GKEMVDYIAD-------YLDGI-----------------EGRPVYPDVEPGYLRPLIPATAPQEP 50

  Fly    69 ETENCSLAEIEELCQQ-VIHYSVKTSHGRFHNQLFGQLDPFGLA-GALVTEAMNGST----YTYE 127
            ||....:.:||::... |.|:         |:..|....|...: .|::.:.:.|:.    :::.
Mouse    51 ETYEDIIKDIEKIIMPGVTHW---------HSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWA 106

  Fly   128 VAPVFSLIETEVIATICK--------LAGYK-EGDGIFAPGGSTSNMYGMVLARYKI-------A 176
            .:|..:.:||.::..:.|        |||.. ||.|:.....|.:.:..::.||.|:       :
Mouse   107 ASPACTELETVMMDWLGKMLELPEAFLAGRAGEGGGVIQGSASEATLVALLAARTKVIRQLQAAS 171

  Fly   177 PEVKTSGMFGMRPLVLFTSDESHYSFVKAANWLGL-GSYNCVSVRTNERGQMLLDDLEAKIAEAK 240
            ||...:.:  |..||.:|||::|.|..:|    || |.....:|.::....|....|...:...|
Mouse   172 PEFTQAAI--MEKLVAYTSDQAHSSVERA----GLIGGIKLKAVPSDGNFSMRASALREALERDK 230

  Fly   241 ARGGEPFFVNCTAGTTVLGAFDDINGAADVTERHGLWLHVDACLGGAALLSAKNRSLIAGLERAN 305
            |.|..||||..|.|||...:||::.....:..:.|:|||:||...|:|.:..:.|.|:.|:|.|:
Mouse   231 AAGLIPFFVVATLGTTSCCSFDNLLEVGPICNQEGVWLHIDAAYAGSAFICPEFRYLLNGVEFAD 295

  Fly   306 SFSWNPHKTIGAPLQCSLFLTRESGRLLERCNSTEAHYLFQQDKFY------DVSYDTGNK--SV 362
            ||::||||.:.....||....:      .|.:.|.|   |..|..|      |..:.|..:  .:
Mouse   296 SFNFNPHKWLLVNFDCSAMWVK------RRTDLTGA---FNMDPVYLKHSHQDSGFITDYRHWQI 351

  Fly   363 QCGRKIDAFKFWLMLKARGYGKYGLM--VDHAIHIARLLEGKLRQRGDRFRLVIPEHEYSNVCFW 425
            ..||:..:.|.|.:.  |.||..||.  :...:.::...|..:|| ..||. :..|.....|||
Mouse   352 PLGRRFRSLKMWFVF--RMYGVKGLQAYIRKHVELSHEFESLVRQ-DPRFE-ICTEVILGLVCF- 411

  Fly   426 FIPKAMRVSSEEETPEWWSRLYTVAPKI 453
                  |:....|..|...:....|.||
Mouse   412 ------RLKGSNELNETLLQRINSAKKI 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5618	NP_649211.1	AAT_I	97..504	CDD:302748	102/389 (26%)
Ddc	NP_001177377.1	Pyridoxal_deC	35..414	CDD:395219	107/413 (26%)
Ddc	NP_001177377.1	2 X approximate tandem repeats	58..178		25/128 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810