DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5618 and gad3

DIOPT Version :9

Sequence 1:	NP_649211.1	Gene:	CG5618 / 40241	FlyBaseID:	FBgn0036975	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001083039.2	Gene:	gad3 / 100038790	ZFINID:	ZDB-GENE-070424-80	Length:	546	Species:	Danio rerio

Alignment Length:	540	Identity:	239/540 - (44%)
Similarity:	322/540 - (59%)	Gaps:	54/540 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ESVDGAETVDQIRDGLMDDWKILENVFHLLRKEDTFCVDPQKWDKQKIVPFLQPDKLKELINLKV 67
            :|.....:::...|||..|...:.:.|..:..:|..   |.:..::....|||     ||:|:.:
Zfish    21 KSKQDTSSLENTDDGLKYDSGRVTHDFSCIHSKDLL---PAEDGEEATKHFLQ-----ELVNILL 77

  Fly    68 --------RET---------------ENCSLA------EIEEL---CQQVIHYSVKTSHGRFHNQ 100
                    |.|               |..||.      .:|:|   |:..:.|.|||.|.||.||
Zfish    78 AYISKSLKRSTKVLDFHYPHQLNEGLEGFSLELPDQPDNLEQLLVDCRDTLKYGVKTGHPRFFNQ 142

  Fly   101 LFGQLDPFGLAGALVTEAMNGSTYTYEVAPVFSLIETEVIATICKLAGYKE--GDGIFAPGGSTS 163
            |...||..||||..:|...|.:.:|||::|||.|:|..|:..:..:.|:.|  |||||.||||.|
Zfish   143 LSTGLDIVGLAGEWLTSTANTNMFTYEISPVFILMEEVVLRKMHTIIGWPEEDGDGIFCPGGSMS 207

  Fly   164 NMYGMVLARYKIAPEVKTSGMFGMRPLVLFTSDESHYSFVKAANWLGLGSYNCVSVRTNERGQML 228
            |:|.::|||:.:.|.|||.||..:..|.:|||..||||..|:|..||:|:.|.:.||.:|||:|:
Zfish   208 NLYSVLLARFHLFPAVKTHGMCAIPRLAMFTSAHSHYSIKKSAAVLGIGTENVIVVRCDERGKMI 272

  Fly   229 LDDLEAKIAEAKARGGEPFFVNCTAGTTVLGAFDDINGAADVTERHGLWLHVDACLGGAALLSAK 293
            ..:|.:.|.|||::|..||:||.||||||.||||.::..||:.|.||||:||||..||..|||.|
Zfish   273 SSELNSSIEEAKSKGLVPFYVNATAGTTVYGAFDPLHKIADICEHHGLWMHVDAAWGGGLLLSNK 337

  Fly   294 NRSLIAGLERANSFSWNPHKTIGAPLQCSLFLTRESGRLLERCNSTEAHYLFQQDKFYDVSYDTG 358
            :|..:.|:|||:|.:|||||.:|.|||||..|.:..| ||::||...|.||||.||.|:||||||
Zfish   338 HRVKLHGIERAHSVTWNPHKMMGVPLQCSTILVKRKG-LLQQCNQLCAEYLFQPDKHYEVSYDTG 401

  Fly   359 NKSVQCGRKIDAFKFWLMLKARGYGKYGLMVDHAIHIARLLEGKLRQRGDRFRLVI---PEHEYS 420
            :||:||||.:|.||.|||.||:|...:...|:|.:..|..|..||::|.| |:||.   |||  |
Zfish   402 DKSIQCGRHVDIFKLWLMWKAKGSEGFESQVNHCLENAEYLYYKLKRRTD-FQLVFKGKPEH--S 463

  Fly   421 NVCFWFIPKAMRVSSEEETPEWWSRLYTVAPKIKEQMAHSGTLMIGYSPLKAKNLGNFFRMVFTC 485
            |||||::||  ||.:....||....|:.||||||.:|...|..||||.||:.|  .||||.||:
Zfish   464 NVCFWYLPK--RVQNIPLGPEREKELHMVAPKIKTKMMEEGFTMIGYQPLEDK--VNFFRCVFS- 523

  Fly   486 FPILKSKELDFILDEIERLG 505
            .|..:.:::||:||||.|||
Zfish   524 NPATQREDVDFLLDEIVRLG 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5618	NP_649211.1	AAT_I	97..504	CDD:302748	208/411 (51%)
gad3	NP_001083039.2	Pyridoxal_deC	96..469	CDD:278699	184/376 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0076
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62386
OrthoDB	1	1.010	-	-		D162307at33208
OrthoFinder	1	1.000	-	-		FOG0000667
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100596
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.730