DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbbp5 and SWD1

DIOPT Version :9

Sequence 1:	NP_649209.1	Gene:	Rbbp5 / 40239	FlyBaseID:	FBgn0036973	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_009403.1	Gene:	SWD1 / 851265	SGDID:	S000000064	Length:	426	Species:	Saccharomyces cerevisiae

Alignment Length:	421	Identity:	125/421 - (29%)
Similarity:	206/421 - (48%)	Gaps:	65/421 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNLELLESFG--QNYPEEFDGSLDCISLAVTC-AFNKYGTLLAVGCNDGRIVIWDFLT-RGI--- 58
            ||:.|.:.|.  :.:||:...::: ..|...| .|:..|..||:||.:|.:||:|..| |.|
Yeast     1 MNILLQDPFAVLKEHPEKLTHTIE-NPLRTECLQFSPCGDYLALGCANGALVIYDMDTFRPICVP 64

  Fly    59 AKIISAHVHPVCSLSWTRNGHKLLSASTDNNVCIWDVLTGELEHK-YRFPSPVLKVQFDPRNDNR 122
            ..::.|||.|:.|::|:.:|..||::|.|.::.:||:.......| .||.||:...|:   .|.:
Yeast    65 GNMLGAHVRPITSIAWSPDGRLLLTSSRDWSIKLWDLSKPSKPLKEIRFDSPIWGCQW---LDAK 126

  Fly   123 LLVCPMRYAAVLVEVGGTHRCLPLDSDGDLNIVASFDRRGKHIYTGNAKGKILVLDVETFEVVAS 187
            ..:|    .|.:.|....: .:...:|...::::..|.  |.:.:....|.:||..|.|.....
Yeast   127 RRLC----VATIFEESDAY-VIDFSNDPVASLLSKSDE--KQLSSTPDHGYVLVCTVHTKHPNI- 183

  Fly   188 FRIIVGTS-----------------------SATAVKSIEFARRGDAFLINTSDRVIRVYDSKEI 229
              ||||||                       :::.:|.:..::.|:...||.|||.||.|:
Yeast   184 --IIVGTSKGWLDFYKFHSLYQTECIHSLKITSSNIKHLIVSQNGERLAINCSDRTIRQYE---- 242

  Fly   230 ITLGKDGEPEPIQ-----KLQDLVNKTTWKKCCFSGD-GEYICAGS--ARQHALYIWEKSIGNLV 286
              :..|.|...::     |.||::||..|....||.: .||:.|.:  :..|.|||||.:.|.||
Yeast   243 --ISIDDENSAVELTLEHKYQDVINKLQWNCILFSNNTAEYLVASTHGSSAHELYIWETTSGTLV 305

  Fly   287 KILHGTKGELLLDVVW--HPVRPIIASISSGLVSIWAQNQVENWSAFAPDFKELDENVEYEERES 349
            ::|.|.:.| |:|:.|  :.:..:.....||.|.:|:......|||.||||:|::|||:|.|:|.
Yeast   306 RVLEGAEEE-LIDINWDFYSMSIVSNGFESGNVYVWSVVIPPKWSALAPDFEEVEENVDYLEKED 369

  Fly   350 EFDIADEDKSVDLNADAQQDEEIEVDVQKVE 380
            |||..||   .:.....:|:|||.:|::..|
Yeast   370 EFDEVDE---AEQQQGLEQEEEIAIDLRTRE 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbbp5	NP_649209.1	WD40	28..321	CDD:295369	92/331 (28%)
		WD40 repeat	29..64	CDD:293791	14/39 (36%)
		WD40	<30..340	CDD:225201	101/348 (29%)
		WD40 repeat	70..107	CDD:293791	11/37 (30%)
		WD40 repeat	110..147	CDD:293791	5/36 (14%)
		WD40 repeat	153..189	CDD:293791	7/35 (20%)
		WD40 repeat	200..245	CDD:293791	13/49 (27%)
		WD40 repeat	253..290	CDD:293791	15/39 (38%)
		WD40 repeat	297..320	CDD:293791	6/24 (25%)
SWD1	NP_009403.1	WD40	10..341	CDD:421866	95/351 (27%)
		WD40 repeat	31..63	CDD:293791	14/31 (45%)
		WD40 repeat	76..113	CDD:293791	10/36 (28%)
		WD40 repeat	117..167	CDD:293791	8/59 (14%)
		WD40 repeat	174..205	CDD:293791	8/33 (24%)
		WD40 repeat	217..257	CDD:293791	12/45 (27%)
		WD40 repeat	264..309	CDD:293791	17/44 (39%)
		WD40 repeat	316..340	CDD:293791	5/23 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157342023
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1273
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3709
Inparanoid	1	1.050	148	1.000	Inparanoid score	I1138
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54438
OrthoFinder	1	1.000	-	-		FOG0005106
OrthoInspector	1	1.000	-	-		oto99276
orthoMCL	1	0.900	-	-		OOG6_103359
Panther	1	1.100	-	-	LDO	PTHR44040
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1420
SonicParanoid	1	1.000	-	-		X3627
TreeFam	1	0.960	-	-
	14	13.790