DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rbbp5 and swd1

DIOPT Version :9

Sequence 1:	NP_649209.1	Gene:	Rbbp5 / 40239	FlyBaseID:	FBgn0036973	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_593795.1	Gene:	swd1 / 2541776	PomBaseID:	SPAC23H3.05c	Length:	398	Species:	Schizosaccharomyces pombe

Alignment Length:	425	Identity:	150/425 - (35%)
Similarity:	220/425 - (51%)	Gaps:	52/425 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNLELLESFG-QNYPEEFDGSLDCISLAVTCAFNKYGTLLAVGCNDGRIVIWDFLTRGIAKIISA 64
            ||||||:.|. .:|||....:|. ...|.:..|:..|..||.|..:|.:||||..|..::::::.
pombe     1 MNLELLDPFSIPDYPEALTTTLK-HGHATSIRFSTNGYHLASGLVNGSVVIWDLSTFSVSRVLTG 64

  Fly    65 HVHPVCSLSWTRNGHKLLSASTDNNVCIWDVLTGELEHKYRFPSPVLKVQFDPRNDNRLLVCPMR 129
            |...:.|:.|:.....||:||.|....:||:..|.:.::....:||......|...|..:...:.
pombe    65 HTRAIQSVCWSSCDRFLLTASRDWKCILWDLRDGSIVYQVVLSAPVWSASLHPHKINTFVASLLD 129

  Fly   130 YAAVLVEVGG---THRCLPLDSDGDLN------------IVASFDRRGKHIYTGNAKGKILVLDV 179
            .:..|:.|..   .|:.||.:.|.|.|            :|:.|...|::|.:|.:||...|:|.
pombe   130 ESPQLIIVDDGIPKHKYLPTNPDIDENYSDRRNRSKHVTLVSFFHPSGEYILSGTSKGWFHVIDA 194

  Fly   180 ETFEVVASFRIIVGTSSATAVKSIEFARRGDAFLI-NTSDRVIRVYDSKEIITLGKDGEPEPIQK 243
            .|.::.:|.||   ||.:.....:.|.:|   ||| |::|||||....:::      ..||...|
pombe   195 STTKIRSSHRI---TSQSIKQIRLSFCKR---FLIFNSTDRVIRTVSIQDL------DNPEVEHK 247

  Fly   244 LQDLVNKTTWKKCCFSGDGEYICAGSARQ-HALYIWEKSIGNLVKILHGTKGELLLDVVWHPVRP 307
            .||:||:..|..|.||..||::.|.:.:. ||:|:||:.:|:|||||.|.|.| |:||.||||.|
pombe   248 FQDVVNRLQWNSCGFSQTGEFVFATTYQMAHAIYVWERGMGSLVKILEGPKEE-LVDVDWHPVFP 311

  Fly   308 IIASI--SSGLVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIADEDKSVDLNADAQQDE 370
            .:||:  .||.:.|||..|.|:||||||||:||:||:||||.|.||||.||       ....::|
pombe   312 CVASVGLDSGSIYIWAVEQKESWSAFAPDFQELEENIEYEEPEDEFDIHDE-------TGKSEEE 369

  Fly   371 EIEVDVQKVEPVAAFCSSDEEGEDENALQFLPMAP 405
            |....|.|:.|           .|.:|.|...|.|
pombe   370 EYFTSVVKILP-----------HDSSAEQPFVMPP 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbbp5	NP_649209.1	WD40	28..321	CDD:295369	101/311 (32%)
		WD40 repeat	29..64	CDD:293791	11/34 (32%)
		WD40	<30..340	CDD:225201	115/328 (35%)
		WD40 repeat	70..107	CDD:293791	10/36 (28%)
		WD40 repeat	110..147	CDD:293791	8/39 (21%)
		WD40 repeat	153..189	CDD:293791	12/47 (26%)
		WD40 repeat	200..245	CDD:293791	14/45 (31%)
		WD40 repeat	253..290	CDD:293791	17/37 (46%)
		WD40 repeat	297..320	CDD:293791	12/24 (50%)
swd1	NP_593795.1	WD40	18..327	CDD:295369	103/322 (32%)
		WD40	<28..342	CDD:225201	112/326 (34%)
		WD40 repeat	28..64	CDD:293791	11/35 (31%)
		WD40 repeat	70..105	CDD:293791	10/34 (29%)
		WD40 repeat	110..152	CDD:293791	8/41 (20%)
		WD40 repeat	168..206	CDD:293791	13/40 (33%)
		WD40 repeat	252..295	CDD:293791	19/42 (45%)
		WD40 repeat	302..326	CDD:293791	11/23 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	169	1.000	Domainoid score	I904
eggNOG	1	0.900	-	-		E1_KOG1273
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3709
Inparanoid	1	1.050	222	1.000	Inparanoid score	I901
OMA	1	1.010	-	-		QHG54438
OrthoFinder	1	1.000	-	-		FOG0005106
OrthoInspector	1	1.000	-	-		oto100845
orthoMCL	1	0.900	-	-		OOG6_103359
Panther	1	1.100	-	-	LDO	PTHR44040
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1420
SonicParanoid	1	1.000	-	-		X3627
TreeFam	1	0.960	-	-
	14	13.860