DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rbbp5 and rbbp-5

DIOPT Version :9

Sequence 1:	NP_649209.1	Gene:	Rbbp5 / 40239	FlyBaseID:	FBgn0036973	Length:	489	Species:	Drosophila melanogaster
Sequence 2:	NP_495222.2	Gene:	rbbp-5 / 174019	WormBaseID:	WBGene00017683	Length:	454	Species:	Caenorhabditis elegans

Alignment Length:	433	Identity:	178/433 - (41%)
Similarity:	261/433 - (60%)	Gaps:	36/433 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LELLE-SFGQNYPEEFDGSLDCISLAVTCA-FNKYGTLLAVGCNDGRIVIWDFLTRGIAKIISAH 65
            :|:|: ::|..:|||.:..||..:.:..|. ||::|:::||||.|||::|:||:||.||:..|||
Worm     2 VEILDRTYGAQFPEELECHLDLQNASANCCKFNRWGSIVAVGCTDGRVLIYDFMTRNIARTFSAH 66

  Fly    66 VHPVCSLSWTRNGHKLLSASTDNNVCIWDVLTGELEHKYRFPSPVLKVQFDPRNDNRLLVCPM-- 128
            ..||..|||:|:|.|||::|.||::.::|||.|.|.|:.||.|.|....|.|||||:.:|..:
Worm    67 CLPVSCLSWSRDGRKLLTSSADNSIAMFDVLAGTLLHRIRFNSMVTFAMFHPRNDNKAIVLQVNK 131

  Fly   129 ---------RYAAVLVEVGGTHRCLPLDSDGDLNIVASFDRRGKHIYTGNAKGKILVLDVETFEV 184
                     |...||.      ...|..||...:.| |:||:||:|..|..|||:|:.:.||.:.
Worm   132 QPTVEQFSPRIQTVLA------NDTPGSSDESASCV-SYDRKGKYIIAGTGKGKLLIYNAETLKC 189

  Fly   185 VASFRIIVGTSSATAVKSIEFARRGDAFLINTSDRVIRVYDSKEIITLGKDGE-PEPIQKLQDLV 248
            ||..:    .::...::.|....:....:.||.|||||.|:.:::  |.:.|: .|...|:.|:|
Worm   190 VAWCK----QNTVQQIRQIIVPMKSRFIITNTQDRVIRTYELEDL--LHQRGQMVEAKYKVLDMV 248

  Fly   249 NKTTWKKCCFSGDGEYICAGSARQHALYIWEKSIGNLVKILHGTKGELLLDVVWHPVRPIIASIS 313
            ||..||..|...||.|:|..|.:.|:|||||.:.|:|:|||||.|||.||||.|||.||||.||:
Worm   249 NKAAWKNVCTDSDGLYVCGASTKAHSLYIWESNTGSLIKILHGNKGEALLDVQWHPTRPIILSIA 313

  Fly   314 SGLVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIADEDKSVDLNADAQQDEEIEVDVQK 378
            .|.||:|.|..|||||||||:|:||:||.:|.|:|:|||:.|||...|:.:.:|..|:..:||..
Worm   314 QGTVSMWTQAHVENWSAFAPEFQELEENEKYIEKENEFDMEDEDADEDMTSKSQDAEDDIIDVVN 378

  Fly   379 VEPVAAFCSSDEE---------GEDENALQFLPMAPEVEDPED 412
            |.|.....|||||         ..:...|.::|:..::|:.::
Worm   379 VRPEDYLASSDEEDCNIMKPARNLESGPLWYIPVPLDIENADN 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rbbp5	NP_649209.1	WD40	28..321	CDD:295369	130/305 (43%)
		WD40 repeat	29..64	CDD:293791	18/35 (51%)
		WD40	<30..340	CDD:225201	144/322 (45%)
		WD40 repeat	70..107	CDD:293791	18/36 (50%)
		WD40 repeat	110..147	CDD:293791	12/47 (26%)
		WD40 repeat	153..189	CDD:293791	16/35 (46%)
		WD40 repeat	200..245	CDD:293791	13/45 (29%)
		WD40 repeat	253..290	CDD:293791	18/36 (50%)
		WD40 repeat	297..320	CDD:293791	16/22 (73%)
rbbp-5	NP_495222.2	WD40	17..320	CDD:295369	132/315 (42%)
		WD40 repeat	30..65	CDD:293791	18/34 (53%)
		WD40	<38..340	CDD:225201	140/314 (45%)
		WD40 repeat	107..151	CDD:293791	13/49 (27%)
		WD40 repeat	159..194	CDD:293791	16/35 (46%)
		WD40 repeat	201..246	CDD:293791	13/46 (28%)
		WD40 repeat	254..290	CDD:293791	17/35 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157543
Domainoid	1	1.000	239	1.000	Domainoid score	I1275
eggNOG	1	0.900	-	-		E1_KOG1273
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3709
Inparanoid	1	1.050	331	1.000	Inparanoid score	I1435
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54438
OrthoDB	1	1.010	-	-		D1001705at2759
OrthoFinder	1	1.000	-	-		FOG0005106
OrthoInspector	1	1.000	-	-		oto17426
orthoMCL	1	0.900	-	-		OOG6_103359
Panther	1	1.100	-	-	LDO	PTHR44040
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1420
SonicParanoid	1	1.000	-	-		X3627
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800