DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn77Bc and SERPINB7

DIOPT Version :9

Sequence 1:	NP_001262103.1	Gene:	Spn77Bc / 40236	FlyBaseID:	FBgn0036970	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001035237.1	Gene:	SERPINB7 / 8710	HGNCID:	13902	Length:	380	Species:	Homo sapiens

Alignment Length:	409	Identity:	98/409 - (23%)
Similarity:	172/409 - (42%)	Gaps:	64/409 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LQKMTDARLQFALNLLQMESTHLNLENFAMTPFSTWSLMIMFYEGAEGTTLKQIRDVLAIYVDYP 94
            :..:..|..:|..||.:....:....|...:..|.::.:.:...||:..:|.||..:|.:..
Human     1 MASLAAANAEFCFNLFREMDDNQGNGNVFFSSLSLFAALALVRLGAQDDSLSQIDKLLHVNT--- 62

  Fly    95 TLRRWYEDVRAYHYLNSENT---------KLFSLRYAYYDDVGDLELVKGYNSVVLEGVGEGNV- 149
                      |..|.||.|:         ::||...|.:.|. ||.:|.|..:..:.|..:..:
Human    63 ----------ASGYGNSSNSQSGLQSQLKRVFSDINASHKDY-DLSIVNGLFAEKVYGFHKDYIE 116

  Fly   150 ---VLREGRPRGVDFD---QGASIIINDDIDKASHAKIFSSYSRRSFNSTVTVLGITVSYFKAKW 208
               .|.:.:...|||.   :.....||..::..:|.||.:.......:|:..::.:...|||.||
Human   117 CAEKLYDAKVERVDFTNHLEDTRRNINKWVENETHGKIKNVIGEGGISSSAVMVLVNAVYFKGKW 181

  Fly   209 KYPFDKSQTKVEQFYNAGGSP--AGK-VEMMVQTGKYAYVNNVKGLQADVLELPFGEHELVMIVI 270
            :..|.||:|....|    .||  :|| |.||.|..|: .::.::.....:|||.: ...:.|.|:
Human   182 QSAFTKSETINCHF----KSPKCSGKAVAMMHQERKF-NLSVIEDPSMKILELRY-NGGINMYVL 240

  Fly   271 LPKPSQRVSLVLKQLKN-LGLHRLLEELEASKNESD-VEVKLPKFDTRSVLSLEDTVYEAGLTDL 333
            ||:..      |.:::| |....|:|.....:..|. |||..|:|.......::..:...||.|:
Human   241 LPEND------LSEIENKLTFQNLMEWTNPRRMTSKYVEVFFPQFKIEKNYEMKQYLRALGLKDI 299

  Fly   334 RNEF-ADLGRMLIPTGDRGAYLSLYHQFARIVVDEEGLPNAVPQKSSGTNNIK--------FHIN 389
            .:|. |||..  |.:|.| .|:|.....:.|.|.|||.....   ::|:|.::        |..:
Human   300 FDESKADLSG--IASGGR-LYISRMMHKSYIEVTEEGTEATA---ATGSNIVEKQLPQSTLFRAD 358

  Fly   390 RPFAYLVLQRTHKLLIHSG 408
            .||.:::  |...:::.||
Human   359 HPFLFVI--RKDDIILFSG 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Bc	NP_001262103.1	SERPIN	36..410	CDD:238101	98/403 (24%)
SERPINB7	NP_001035237.1	serpinB7_megsin	1..380	CDD:381032	98/409 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.020