DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn77Bc and SERPINH1

DIOPT Version :9

Sequence 1:	NP_001262103.1	Gene:	Spn77Bc / 40236	FlyBaseID:	FBgn0036970	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001193943.1	Gene:	SERPINH1 / 871	HGNCID:	1546	Length:	418	Species:	Homo sapiens

Alignment Length:	409	Identity:	91/409 - (22%)
Similarity:	149/409 - (36%)	Gaps:	120/409 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ALNLLQMESTHLNLENFAMTPFSTWSLMIMFYEGAEGTTLKQIRDVLAIYVDYPTLRRWYEDVRA 105
            |.:|.|..:....:||..::|....|.:.:...|.:.||..|.:.||:.    ..||.  |:|.|
Human    51 AFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSA----EQLRD--EEVHA 109

  Fly   106 YHYLNSENTKLFSLRYAYYDDVGDLELVKGYNSVVLEGVGEGNVVLREGRPRGVDFDQG------ 164
                                                 |:||....|.....|.|.:..|
Human   110 -------------------------------------GLGELLRSLSNSTARNVTWKLGSRLYGP 137

  Fly   165 ASIIINDDIDKAS-------HAKIFSSYSRRSFNS----------------------TVTVLGIT 200
            :|:...||..::|       |:||.....|.:..|                      |...|.:.
Human   138 SSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVN 202

  Fly   201 VSYFKAKWKYPF-----DKSQTKVEQFYNAGGSPAGKVEMMVQTGKYAYVNNVKGLQADVLELPF 260
            ..:||..|...|     |.....|.:.|..|      |.||.:||.|.|.::.|. :..::|:|.
Human   203 AMFFKPHWDEKFHHKMVDNRGFMVTRSYTVG------VMMMHRTGLYNYYDDEKE-KLQIVEMPL 260

  Fly   261 GEHELVMIVILP---KPSQRVSLVLKQLKNLGLHRLLEELE---ASKNESDVEVKLPKFDTRSVL 319
            ......:|:::|   :|.:|:..:|.:          |:|:   ....:..|.:.|||.......
Human   261 AHKLSSLIILMPHHVEPLERLEKLLTK----------EQLKIWMGKMQKKAVAISLPKGVVEVTH 315

  Fly   320 SLEDTVYEAGLTDL--RNEFADLGRMLIPTGDRGAYL-SLYHQFARIVVDEEGLPNAVPQKSSGT 381
            .|:..:...|||:.  :|: |||.||   :|.:..|| |::|..| ..:|.:|  |...|...|.
Human   316 DLQKHLAGLGLTEAIDKNK-ADLSRM---SGKKDLYLASVFHATA-FELDTDG--NPFDQDIYGR 373

  Fly   382 NNIK----FHINRPFAYLV 396
            ..::    |:.:.||.:||
Human   374 EELRSPKLFYADHPFIFLV 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Bc	NP_001262103.1	SERPIN	36..410	CDD:238101	91/409 (22%)
SERPINH1	NP_001193943.1	serpinH1_CBP1	36..417	CDD:381003	91/409 (22%)
SERPINH1	NP_001193943.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	415..418
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020