DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn77Bc and Serpinb12

DIOPT Version :9

Sequence 1:	NP_001262103.1	Gene:	Spn77Bc / 40236	FlyBaseID:	FBgn0036970	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001186142.1	Gene:	Serpinb12 / 71869	MGIID:	1919119	Length:	423	Species:	Mus musculus

Alignment Length:	324	Identity:	83/324 - (25%)
Similarity:	143/324 - (44%)	Gaps:	49/324 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 RAYHYLNSEN----TKLFSLRYAYYDDVGDLELVKGYNSVVLEGVGEGNVVLREGRPRGVDFDQG 164
            ::|:.|:..|    .:.|.:...|.|||.:.     :::.|                ..|||.:.
Mouse   125 KSYYTLSMANRLYGEQEFPICSEYSDDVTEF-----FHTTV----------------ESVDFQKD 168

  Fly   165 ASII---INDDIDKASHAKIFSSYSRRSF-NSTVTVLGITVSYFKAKWKYPFDKSQTKVEQFYNA 225
            :...   ||..::..|..||...:.:.:. ||||.|| :...||||||:..|: |:..|:..:..
Mouse   169 SEKSRQEINFWVESQSQGKIKELFGKEAIDNSTVLVL-VNAVYFKAKWEREFN-SENTVDASFCL 231

  Fly   226 GGSPAGKVEMMVQTGKYAYVNNVKGLQADVLELPFGEHELVMIVILPKPSQRVSLVLKQLKNLGL 290
            ..:....|:||.|.||:. :..:..|||.:||:.:...:|.|:|:||..|:.....|::|:....
Mouse   232 NENEKKTVKMMNQKGKFR-IGFIDELQAQILEMKYAMGKLSMLVLLPSCSEDNVNSLQELEKKIN 295

  Fly   291 HRLLEELEASKN--ESDVEVKLPKFDTRSVLSLEDTVYEAGLTDLRNEF-ADLGRMLIPTG---D 349
            |..|....:|:|  |..|.:..|:|:......|:..:.:.|:.|:.:|. |||      ||   .
Mouse   296 HEKLLAWSSSENLSEKPVAISFPQFNLEDSYDLKSILQDMGIKDVFDETKADL------TGISKS 354

  Fly   350 RGAYLSLYHQFARIVVDEEGLPNA-----VPQKSSGTNNIKFHINRPFAYLVLQRTHKLLIHSG 408
            ...|||.......:.|||.|...|     |..:.:..:.::|:.|.||.:.:.....:.|:..|
Mouse   355 PNLYLSKIVHKTFVEVDEMGTQAAAASGVVAAEKALPSWVEFNANHPFLFFIRHNPTQSLLFCG 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Bc	NP_001262103.1	SERPIN	36..410	CDD:238101	83/324 (26%)
Serpinb12	NP_001186142.1	SERPIN	4..423	CDD:294093	83/324 (26%)
Serpinb12	NP_001186142.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..106
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020