DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn77Bc and SERPINE3

DIOPT Version :9

Sequence 1:	NP_001262103.1	Gene:	Spn77Bc / 40236	FlyBaseID:	FBgn0036970	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001094790.1	Gene:	SERPINE3 / 647174	HGNCID:	24774	Length:	424	Species:	Homo sapiens

Alignment Length:	398	Identity:	95/398 - (23%)
Similarity:	169/398 - (42%)	Gaps:	64/398 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LLQKMTDARLQFALNLLQMESTHLNLENFAMTPFSTWSLMIMFYEGAEGTTLKQIRDVLAIYVDY 93
            |.:.||..:.:|||:|.|..:...|..||.::|......:.:...||||:|.:|:.|.|...|..
Human    22 LREGMTLLKTEFALHLYQSVAACRNETNFVISPAGVSLPLEILQFGAEGSTGQQLADALGYTVHD 86

  Fly    94 PTLRRWYEDVRAYHYLNSENTKLFSLRYAYYDDVGD------LELVKGYNSVVLEGVGEGNVVLR 152
            ..::.:...|.|....:|:.|:: .|..:.:..||.      :|.|..:.:..||...     |.
Human    87 KRVKDFLHAVYATLPTSSQGTEM-ELACSLFVQVGTPLSPCFVEHVSWWANSSLEPAD-----LS 145

  Fly   153 EGRPRGVDFDQGASIIINDDIDKASHA-----------KIFSSYSRRSFNSTVTVLGITVSYFKA 206
            |.....:...:|||      .:.|...           ::.:::::....||::        |:.
Human   146 EPNSTAIQTSEGAS------RETAGGGPSEGPGGWPWEQVSAAFAQLVLVSTMS--------FQG 196

  Fly   207 KWKYPFDKSQTKVEQFYNAGGSPAGKVEMMVQTGK--YAYVNNVKGLQADVLELPFGEHELVMIV 269
            .|:..|..:.|::..|..|.|... :|.||.||.:  |....:..|.|..|||||:....:.:.:
Human   197 TWRKRFSSTDTQILPFTCAYGLVL-QVPMMHQTTEVNYGQFQDTAGHQVGVLELPYLGSAVSLFL 260

  Fly   270 ILPKPSQR-VSLVLKQLKNLGLHRLLEELEASKNESDVEVKLPKFDTRSVLSLEDTVYEAGLTDL 333
            :||:.... :|.:...|....:|.....|..::    ::|.||:|..::..:|:..:...|:|||
Human   261 VLPRDKDTPLSHIEPHLTASTIHLWTTSLRRAR----MDVFLPRFRIQNQFNLKSILNSWGVTDL 321

  Fly   334 RNEF-ADLGRMLIPTGDRGAYLSLYHQFARIVVDEEGLPNAVPQKSSGTNNIK---------FHI 388
            .:.. |:|..:   :|..|.|:|.....|:|.|.|||      .|:||...:.         |..
Human   322 FDPLKANLKGI---SGQDGFYVSEAIHKAKIEVLEEG------TKASGATALLLLKRSRIPIFKA 377

  Fly   389 NRPFAYLV 396
            :|||.|.:
Human   378 DRPFIYFL 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Bc	NP_001262103.1	SERPIN	36..410	CDD:238101	92/391 (24%)
SERPINE3	NP_001094790.1	SERPIN	31..399	CDD:238101	92/389 (24%)
SERPINE3	NP_001094790.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..174		6/41 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920