DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn77Bc and SERPINB4

DIOPT Version :9

Sequence 1:	NP_001262103.1	Gene:	Spn77Bc / 40236	FlyBaseID:	FBgn0036970	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_002965.1	Gene:	SERPINB4 / 6318	HGNCID:	10570	Length:	390	Species:	Homo sapiens

Alignment Length:	419	Identity:	105/419 - (25%)
Similarity:	174/419 - (41%)	Gaps:	77/419 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 LQKMTDARLQFALNLLQMESTHLNLENFAMTPFSTWSLMIMFYEGAEGTTLKQIRDVLAIYVDYP 94
            :..:::|..:|..:|.| :.......|...:|.|..|.:.|...||:..|.:||..||  :.|..
Human     1 MNSLSEANTKFMFDLFQ-QFRKSKENNIFYSPISITSALGMVLLGAKDNTAQQISKVL--HFDQV 62

  Fly    95 TLRRWYEDVRAYHYLNSEN------------------------TKLFSLR-YAYYDDVGDLELVK 134
            | ....|....||...|.|                        .|||..: |.:..:.  |:.:|
Human    63 T-ENTTEKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYQFLQEY--LDAIK 124

  Fly   135 GYNSVVLEGVGEGNVVLREGRPRGVDFDQGASIIINDDIDKASHAKIFSSYSRRSFNSTVTVLGI 199
            .:....:|.....|.. .|.|.:           ||..::..::.||.:.:...:..:..|::.:
Human   125 KFYQTSVESTDFANAP-EESRKK-----------INSWVESQTNEKIKNLFPDGTIGNDTTLVLV 177

  Fly   200 TVSYFKAKWKYPFDKSQTKVEQFYNAGGSPAGKVEMMVQTGKYAYVNNVKGLQADVLELPFGEHE 264
            ...|||.:|:..|.|..||.|:|: ...:....|:||.|...:.:. .::.:||.|||:|:...:
Human   178 NAIYFKGQWENKFKKENTKEEKFW-PNKNTYKSVQMMRQYNSFNFA-LLEDVQAKVLEIPYKGKD 240

  Fly   265 LVMIVILPKPSQRVSLVLKQLKNLGLHRLLEELEASK----------NESDVEVKLPKFDTRSVL 319
            |.|||:||....            ||.:|.|:|.|.|          .|:.|::.||:|......
Human   241 LSMIVLLPNEID------------GLQKLEEKLTAEKLMEWTSLQNMRETCVDLHLPRFKMEESY 293

  Fly   320 SLEDTVYEAGLTDLRNEFADLGRMLIPTGDRGAYLSLYHQFARIVVDEEGLPNA------VPQKS 378
            .|:||:...|:.::.|..|||..|   |...|..:|.....|.:.|.|||:..|      |.:.|
Human   294 DLKDTLRTMGMVNIFNGDADLSGM---TWSHGLSVSKVLHKAFVEVTEEGVEAAAATAVVVVELS 355

  Fly   379 SGTNNIKFHINRPFAYLVLQ-RTHKLLIH 406
            |.:.|.:|..|.||.:.:.| :|:.:|.:
Human   356 SPSTNEEFCCNHPFLFFIRQNKTNSILFY 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Bc	NP_001262103.1	SERPIN	36..410	CDD:238101	105/413 (25%)
SERPINB4	NP_002965.1	SERPIN	4..390	CDD:320777	105/416 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.020