Protein Alignment Spn77Bc and SERPINA1

DIOPT Version :10

• Sequence 1: NP_649207.1
• Gene: Spn77Bc / 40236
• FlyBaseID: FBgn0036970
• Length: 416
• Species: Drosophila melanogaster
• Sequence 2: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Alignment Length: 407
• Identity: 90/407 - (22%)
• Similarity: 159/407 - (39%)
• Gaps: 75/407 - (18%)

  Fly    32 KMTDARLQFALNLLQMESTHLNLENFAMTPFSTWSLMIMFYEGAEGTTLKQIRDVL--------- 87
            |:|....:||.:|.:..:...|..|...:|.|..:...|...|.:..|..:|.:.|
Human    49 KITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPE 113

  Fly    88 -AIYVDYPTLRRWYEDVRAYHYLNSENTKLFSLRYAYYDDVGDLELVKGYNSVVLEGVG------ 145
             .|:..:..|.|         .||..:::              |:|..|....:.||:.
Human   114 AQIHEGFQELLR---------TLNQPDSQ--------------LQLTTGNGLFLSEGLKLVDKFL 155

  Fly   146 EGNVVLREGRPRGVDF--DQGASIIINDDIDKASHAKIFSSYSRRSFNSTVTVLGITVSYFKAKW 208
            |....|.......|:|  .:.|...|||.::|.:..||........ ..||..| :...:||.||
Human   156 EDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELD-RDTVFAL-VNYIFFKGKW 218

  Fly   209 KYPFDKSQTKVEQFYNAGGSPAGKVEMMVQTGKYAYVNNVKGLQADVLELPF-GEHELVMIVILP 272
            :.||:...|:.|.|: .......||.||.:.|.: .:.:.|.|.:.||.:.: |  ....|..||
Human   219 ERPFEVKDTEEEDFH-VDQVTTVKVPMMKRLGMF-NIQHCKKLSSWVLLMKYLG--NATAIFFLP 279

  Fly   273 KPSQRVSLVLKQLKNLGLHRLLEELEASKNESDVEVKLPKFDTRSVLSLEDTVYEAGLTDLRNEF 337
            ...:     |:.|:|...|.::.:...:::.....:.|||........|:..:.:.|:|.:.:..
Human   280 DEGK-----LQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNG 339

  Fly   338 ADLGRMLIPTGDRGAYLSLYHQFARIVVDEEG-----------LPNAVPQKSSGTNNIKFHINRP 391
            |||..:   |.:....||.....|.:.:||:|           :|.::|.:      :||  |:|
Human   340 ADLSGV---TEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPE------VKF--NKP 393

  Fly   392 FAYLVLQRTHKLLIHSG 408
            |.:|::::..|..:..|
Human   394 FVFLMIEQNTKSPLFMG 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Bc	NP_649207.1	serpin	33..412	CDD:476815	89/406 (22%)
SERPINA1	NP_000286.3	serpinA1_A1AT	50..417	CDD:381012	89/406 (22%)
		RCL	368..392		5/31 (16%)