Protein Alignment Spn77Bc and SERPINE1

DIOPT Version :10

• Sequence 1: NP_649207.1
• Gene: Spn77Bc / 40236
• FlyBaseID: FBgn0036970
• Length: 416
• Species: Drosophila melanogaster
• Sequence 2: NP_001373389.1
• Gene: SERPINE1 / 5054
• HGNCID: 8583
• Length: 492
• Species: Homo sapiens
• Alignment Length: 376
• Identity: 88/376 - (23%)
• Similarity: 152/376 - (40%)
• Gaps: 47/376 - (12%)

  Fly    40 FALNLLQMESTHLNLENFAMTPFSTWSLMIMFYEGAEGTTLKQIRDVLAIYVD----YPTLRRWY 100
            |.:.:.|..:......|...:|:...|::.|......|.|.:||:..:...:|    .|.||..|
Human    38 FGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLY 102

  Fly   101 EDVRAYHYLNSENT--KLFSLRYAYYDDVGDLELVKGYNSVVLEGVGEGNVVLREGRPRGVDFD- 162
            :::......:..:|  .:|..|        ||:||:|:......        |.....:.|||.
Human   103 KELMGPWNKDEISTTDAIFVQR--------DLKLVQGFMPHFFR--------LFRSTVKQVDFSE 151

  Fly   163 -QGASIIINDDIDKASHAKIFSSYSRRSFNSTVTVLGITVSYFKAKWKYPFDKSQTKVEQFYNAG 226
             :.|..||||.:...:...|.:...:.:.:....::.:...||..:||.||..|.|....|:.:.
Human   152 VERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSD 216

  Fly   227 GSPAGKVEMMVQTGKYAYV--NNVKGLQADVLELPFGEHELVMIVILPKPSQRVSLVLKQLKNLG 289
            ||.. .|.||.||.|:.|.  ....|...|:||||:....|.|.:..|...:   :.|..|.|:.
Human   217 GSTV-SVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKE---VPLSALTNIL 277

  Fly   290 LHRLLEELEASKNESDVEVKLPKFDTRSVLSLEDTVYEAGLTDLRNEF-ADLGRMLIPTGDRGAY 353
            ..:|:...:.:.......:.||||...:.:.|...:...|:||:..:| ||...:   :.....:
Human   278 SAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSL---SDQEPLH 339

  Fly   354 LSLYHQFARIVVDEEGLPNAVPQKSSGTNNI--------KFHINRPFAYLV 396
            ::...|..:|.|:|.|     ...||.|..|        :..::|||.::|
Human   340 VAQALQKVKIEVNESG-----TVASSSTAVIVSARMAPEEIIMDRPFLFVV 385

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Bc	NP_649207.1	serpin	33..412	CDD:476815	88/376 (23%)
SERPINE1	NP_001373389.1	serpinE1_PAI-1	29..393	CDD:381007	88/376 (23%)