DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn77Bc and SERPINC1

DIOPT Version :9

Sequence 1:	NP_001262103.1	Gene:	Spn77Bc / 40236	FlyBaseID:	FBgn0036970	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001373231.1	Gene:	SERPINC1 / 462	HGNCID:	775	Length:	505	Species:	Homo sapiens

Alignment Length:	459	Identity:	107/459 - (23%)
Similarity:	171/459 - (37%)	Gaps:	113/459 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TKSLLQKMTDARLQFALNLLQMESTHL-----NLENFAMTPFSTWSLMIMFYEGAEGTTLKQIRD 85
            |...:.:::.|..:||....|    ||     :.:|..::|.|..:...|...||...||:|:.:
Human    76 TNRRVWELSKANSRFATTFYQ----HLADSKNDNDNIFLSPLSISTAFAMTKLGACNDTLQQLME 136

  Fly    86 VLAIYVDYPTLRRWYED----------VRAYHYLNSENTKLFSLRYAY----------YDDVGDL 130
            |.    .:.|:.....|          .|.|...| :::||.|....:          |.|:.
Human   137 VF----KFDTISEKTSDQIHFFFAKLNCRLYRKAN-KSSKLVSANRLFGDKSLTFNETYQDIS-- 194

  Fly   131 ELVKGYNSVVLEGVGEGNVVLREGRPRGVDFDQGAS---IIINDDIDKASHAKIFSSYSRRSFNS 192
            |||.|                  .:.:.:||.:.|.   ..||..:...:..:|.......:.|.
Human   195 ELVYG------------------AKLQPLDFKENAEQSRAAINKWVSNKTEGRITDVIPSEAINE 241

  Fly   193 TVTVLGITVSYFK-----------------------------------------AKWKYPFDKSQ 216
            ...::.:...|||                                         ..||..|....
Human   242 LTVLVLVNTIYFKVLRMALERPQGLPLALQLTPFFFKWRDRSPERANGLPKATQGLWKSKFSPEN 306

  Fly   217 TKVEQFYNAGGSPAGKVEMMVQTGKYAYVNNVKGLQADVLELPFGEHELVMIVILPKPSQRVSLV 281
            |:.|.||.|.|... ...||.|.||:.|....:|.|  ||||||...::.|::|||||.:.::.|
Human   307 TRKELFYKADGESC-SASMMYQEGKFRYRRVAEGTQ--VLELPFKGDDITMVLILPKPEKSLAKV 368

  Fly   282 LKQLKNLGLHRLLEELEASKNESDVEVKLPKFDTRSVLSLEDTVYEAGLTDLRNEFADLGRMLIP 346
            .|:|....|...|:|||    |..:.|.:|:|......||::.:.:.||.||.:........::.
Human   369 EKELTPEVLQEWLDELE----EMMLVVHMPRFRIEDGFSLKEQLQDMGLVDLFSPEKSKLPGIVA 429

  Fly   347 TGDRGAYLS-LYHQFARIVVDEEGLPNA------VPQKSSGTNNIKFHINRPFAYLVLQRTHKLL 404
            .|....|:| .:|: |.:.|:|||...|      :..:|...|.:.|..||||...:.:.....:
Human   430 EGRDDLYVSDAFHK-AFLEVNEEGSEAAASTAVVIAGRSLNPNRVTFKANRPFLVFIREVPLNTI 493

  Fly   405 IHSG 408
            |..|
Human   494 IFMG 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Bc	NP_001262103.1	SERPIN	36..410	CDD:238101	106/449 (24%)
SERPINC1	NP_001373231.1	serpinC1_AT3	70..504	CDD:381002	107/459 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920