DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn77Bc and Serpinb6e

DIOPT Version :9

Sequence 1:	NP_001262103.1	Gene:	Spn77Bc / 40236	FlyBaseID:	FBgn0036970	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001039000.2	Gene:	Serpinb6e / 435350	MGIID:	2667778	Length:	429	Species:	Mus musculus

Alignment Length:	410	Identity:	99/410 - (24%)
Similarity:	174/410 - (42%)	Gaps:	61/410 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 SLLQKMTDARLQFALNLLQM--ESTHLNLENFAMTPFSTWSLMIMFYEGAEGTTLKQIRDVLA-- 88
            :::..:.:|...|.|.|.::  |.:..|:...:.:.||:.:|::|   ||.|||..||..||:
Mouse    51 TIMDSLLEANATFTLKLFRVLGEDSSKNVFFSSSSMFSSLALILM---GANGTTASQISQVLSLD 112

  Fly    89 --------IYVDYPTLRRWYEDVRAYHYLNSENTKLFSLRYAYYDDVGDLELVKGYNSVVLEGVG 145
                    :...:.:|..........|.|...| |:||      |:          |..::|...
Mouse   113 KCSNGGADVQQGFQSLLTEVNKTDTGHMLRRAN-KIFS------DN----------NFDIMESFK 160

  Fly   146 EGNVVLREGRPRGVDF---DQGASIIINDDIDKASHAKIFSSYSRRSFNSTVTVLGITVSYFKAK 207
            |....|.......:||   .:.....||..:.|.:...|....|..:.||...::.:..:|||.|
Mouse   161 ESCYKLYRVEIEKLDFKGTPEQCRQHINAWVAKKTKDVIRELLSLYTVNSNTRLILVNATYFKGK 225

  Fly   208 WKYPFDKSQTKVEQFYNAGGSPAGKVEMMVQ--TGKYAYVNNVKGLQADVLELPFGEHELVMIVI 270
            |:..|:|..|: |..:....:....|:||.:  |.|..|...:   ...::.||:.:.||.||::
Mouse   226 WEKQFNKEDTR-EMPFKVSKNEKKTVQMMSKKSTFKTYYAEEI---STTIVFLPYTDKELSMIIM 286

  Fly   271 LPKPSQRVSLVLKQL--KNLGLHRLLEELEASKNESDVEVKLPKFDTRSVLSLEDTVYEAGLTDL 333
            ||.....:|:|..|:  |.|.....|.::|    |.:|:|.||:|...:...::|.:.:.|:||.
Mouse   287 LPDEQVELSMVENQISYKKLIQWTRLVKME----EEEVQVFLPRFKLEATYDMKDVLCKLGMTDA 347

  Fly   334 ----RNEFADLGRMLIPTGDRGAYLSLYHQFARIVVDEEGLPNAVPQK----SSGTNNIKFHINR 390
                |.:|:.:      :..:|.:||.....:.:.|:|||...||..:    .|.........:|
Mouse   348 FEESRADFSGI------SSKKGLFLSNVVHKSFVEVNEEGTEAAVATEIVTVGSPLTQRCLIADR 406

  Fly   391 PFAYLVLQRTHKLLIHSGVF 410
            ||.:|:.....|.::..|.|
Mouse   407 PFLFLIQGDKSKEILFLGRF 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Bc	NP_001262103.1	SERPIN	36..410	CDD:238101	98/400 (25%)
Serpinb6e	NP_001039000.2	serpin	53..429	CDD:393296	99/408 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020