DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn77Bc and Serpinb1c

DIOPT Version :9

Sequence 1:	NP_001262103.1	Gene:	Spn77Bc / 40236	FlyBaseID:	FBgn0036970	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	XP_006516771.1	Gene:	Serpinb1c / 380839	MGIID:	2445363	Length:	408	Species:	Mus musculus

Alignment Length:	430	Identity:	108/430 - (25%)
Similarity:	173/430 - (40%)	Gaps:	81/430 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 KLGFLGLFGMVLSLRAHICANTVDTKSLLQKMTDARLQFALNLLQMESTHLNLE-----NFAMTP 61
            :|..||:.|:     |.|..| ||..| :...|..:|..|.||..:|..|...|     |...:|
Mouse     8 QLQVLGVGGL-----ADIVGN-VDPPS-VAAFTMGQLSSANNLFALELFHTLNESNPTGNTIFSP 65

  Fly    62 FSTWSLMIMFYEGAEGTTLKQIRDVL------AIYVDYPTLRRWYEDVRAYHYLNSEN----TKL 116
            .|..|.:.|.|.||.|:|..|:...|      .|:..:.:|........|.|.|...|    .|.
Mouse    66 VSISSALAMVYLGARGSTAAQLSKTLHFDSAEDIHSQFQSLTAEVSKRGASHTLKLANRLYGEKT 130

  Fly   117 FSLRYAYYDDV-----GDLELVKGYNSVVLEGVGEGNVVLREGRPRGVDF---DQGASIIINDDI 173
            ::....|...:     .||.|                          |||   .:.|...||..:
Mouse   131 YNFLPEYLASIQKTYSADLAL--------------------------VDFQHASEDARKEINQWV 169

  Fly   174 DKASHAKIFSSYSRRSFNSTVTVLGITVSYFKAKWKYPFDKSQTKVEQFYNAGGSPAGKVEMMVQ 238
            ...:..||...::....:|...::.:..:|||..|:..|....|.        .:|....:.:.:
Mouse   170 KGQTEEKIQELFAVGVVDSMTKLVLVNATYFKGMWQKKFMARDTT--------DAPFRLSKKVTK 226

  Fly   239 TGKYAYVNN------VKGLQADVLELPFGEHELVMIVILPKPSQRVSLVLKQL-KNLGLHRLLEE 296
            |.|..|:.|      :..|:..|||:|:...||.|:::||:..:..:..|::: |.|.|.: |:|
Mouse   227 TVKMMYLKNNLPFGYIPDLKCKVLEMPYQGGELSMVILLPEDIEDETTGLEEIEKQLTLEK-LQE 290

  Fly   297 LEASKNESDVEVKLPKFDTRSVLSLEDTVYEAGLTDL-RNEFADLGRMLIPTGDRGAYLSLYHQF 360
            .|..:| .||.||||||.......|...:.:.|:.|| .:..|||..|   :|.|..::|.....
Mouse   291 CENLQN-IDVCVKLPKFKMEESYILNSNLGQLGVQDLFSSSKADLSGM---SGSRDLFISKIVHK 351

  Fly   361 ARIVVDEEGLPN--AVPQKSSG--TNNIKFHINRPFAYLV 396
            :.:.|:|||...  |:|....|  ...::|.::.||.:.:
Mouse   352 SYVEVNEEGTETDAAMPGTVVGCCLMPMEFTVDHPFLFFI 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Bc	NP_001262103.1	SERPIN	36..410	CDD:238101	97/396 (24%)
Serpinb1c	XP_006516771.1	serpinB1_LEI	34..408	CDD:381028	97/397 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920