DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spn77Bc and SERPINA11

DIOPT Version :9

Sequence 1:	NP_001262103.1	Gene:	Spn77Bc / 40236	FlyBaseID:	FBgn0036970	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001073920.1	Gene:	SERPINA11 / 256394	HGNCID:	19193	Length:	422	Species:	Homo sapiens

Alignment Length:	405	Identity:	88/405 - (21%)
Similarity:	161/405 - (39%)	Gaps:	67/405 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KMTDARLQFALNLLQMESTHLNLE---NFAMTPFSTWSLMIMFYEGAEGTTLKQIRDVLAIYVDY 93
            ::|.....|||.|.:    .|..:   |...:|.|..:.:.:...||:..|...|.:.|...:..
Human    49 RITPTITNFALRLYK----ELAADAPGNIFFSPVSISTTLALLSLGAQANTSALILEGLGFNLTE 109

  Fly    94 PTLRRWYEDVRA-YHYLNSENTKL-------------FSLRYAYYDDVGDLELVKGYNSVVLEGV 144
            ......::..|: .|.|...:.||             ...|..|.|.:.:|.....:::...:.|
Human   110 TPEADIHQGFRSLLHTLALPSPKLELKVGNSLFLDKRLKPRQHYLDSIKELYGAFAFSANFTDSV 174

  Fly   145 GEGNVVLREGRPRGVDFDQGASIIINDDIDKASHAKIFSSYSRRSFNSTVTVLGITVSYFKAKWK 209
            ..|..                   |||.:.:.::.::.......| ..|..||...: :||||||
Human   175 TTGRQ-------------------INDYLRRQTYGQVVDCLPEFS-QDTFMVLANYI-FFKAKWK 218

  Fly   210 YPFDKSQTKVEQFYNAGGSPAGKVEMMVQTGKYAYVNNVKGLQADVLELPFGEHELVMIVILPKP 274
            :||.:.||:.::.:......:.:|.||.|...:.::.: :.|...||::.:..:.|.::| ||.|
Human   219 HPFSRYQTQKQESFFVDERTSLQVPMMHQKEMHRFLYD-QDLACTVLQIEYRGNALALLV-LPDP 281

  Fly   275 SQ----RVSLVLKQLKNLGLHRLLEELEASKNESDVEVKLPKFDTRSVLSLEDTVYEAGLTDLRN 335
            .:    ..:|..:.|:..| ..||..|        :::.||:|......:|||.:.:.|||::.|
Human   282 GKMKQVEAALQPQTLRKWG-QLLLPSL--------LDLHLPRFSISGTYNLEDILPQIGLTNILN 337

  Fly   336 EFADLGRMLIPTGDRGAYLSLYHQFARIVVDEEGLPNAV-------PQKSSGTNNIKFHINRPFA 393
            ..||...:   ||.....:|.....|.:.:.|:|.....       |...:..::...|.||||.
Human   338 LEADFSGV---TGQLNKTISKVSHKAMVDMSEKGTEAGAASGLLSQPPSLNTMSDPHAHFNRPFL 399

  Fly   394 YLVLQRTHKLLIHSG 408
            .|:.:.|.:.|:..|
Human   400 LLLWEVTTQSLLFLG 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Bc	NP_001262103.1	SERPIN	36..410	CDD:238101	87/401 (22%)
SERPINA11	NP_001073920.1	alpha-1-antitrypsin_like	53..416	CDD:239011	87/401 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910