DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn77Bc and Serpina12

DIOPT Version :9

Sequence 1:	NP_001262103.1	Gene:	Spn77Bc / 40236	FlyBaseID:	FBgn0036970	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_620180.2	Gene:	Serpina12 / 191570	RGDID:	708485	Length:	414	Species:	Rattus norvegicus

Alignment Length:	480	Identity:	105/480 - (21%)
Similarity:	182/480 - (37%)	Gaps:	157/480 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LGLFGMVLSLRAHICANTVDTKSLLQ------------------------KMTDARLQFALNLLQ 46
            ||||          .|..:..|.|||                        ::|...::|...|||
  Rat     7 LGLF----------LAGLLTVKGLLQDRDAPDTYESPVRVQEWRGKKDARELTRHNMEFGFKLLQ 61

  Fly    47 MESTHLNLENFAMTPFSTWSLMIMFYEGAEGTTLKQIRDVLAIYVDYPTLRRWYEDV------RA 105
            ..:::....|..::|.|..:...|...||:.:||::||:...           ::::      ..
  Rat    62 RLASNSRQGNIFLSPLSISTAFSMLSLGAQNSTLEEIREGFN-----------FKEMSDRDMHMG 115

  Fly   106 YHYLNSENTKLFSLRYAYYDDVGDLELVKGYNSVVLEGVGEGNVVLREGRPRGVD---------F 161
            :|||..:..:          :..|:::     |:       ||.:..:.|.|...         :
  Rat   116 FHYLLQKLNR----------ETQDVKM-----SI-------GNALFMDQRLRPQQRFLKLAKNLY 158

  Fly   162 DQGASIIINDDIDKASHAKIFSSY-SRRSFN-----------STVTVLGITVSYFKAKWKYPFDK 214
            |  |.:|:.:..|..:..|..:.| ||::.|           .||.:| ....||:.:|:|.||.
  Rat   159 D--ADMILTNFQDLENTQKNINKYISRKTHNRIENMVKNIDPGTVMLL-TNYIYFQGRWQYEFDP 220

  Fly   215 SQTKVEQFYNAGGSPAGKVEMMVQTGKY--AYVNNVKGLQADVLELPFGEHELVMIVILPKPSQR 277
            .|||.|.|:...|... ||.||.|.|.|  ||.:.   |...:||:|: ...:....:||
  Rat   221 KQTKEEDFFIEEGKTV-KVPMMFQRGMYDMAYDSQ---LSCTILEMPY-RRNITATFVLP----- 275

  Fly   278 VSLVLKQLKNLGLHRLLEE-LEA----------SKNESDVEVKLPKFDTRSVLSLEDTVYEAGLT 331
                     :.|..||||: |:|          ||...||.|  |:....:..:::..:...|::
  Rat   276 ---------DSGKLRLLEQGLQADIFAKWKSLLSKRVVDVWV--PRLHISATYNMKKVLSRLGIS 329

  Fly   332 DLRNEFADLGRMLIPTGDRGAYLSL-----YHQFARIVVDEEGLPNAVPQKSSGTNNI------K 385
            .:..|..||.|:       .::.||     .|: |.:.::|:|...|.   .||...:      :
  Rat   330 KIFEEHGDLTRI-------SSHRSLKVGEAVHK-AELRMNEKGTEGAA---GSGAQTLPMETPRR 383

  Fly   386 FHINRPFAYLVLQRTHKLLIHSGVF 410
            ..:|.||..::.:.    |:.|.:|
  Rat   384 MKLNAPFLMMIYEN----LMPSMIF 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Bc	NP_001262103.1	SERPIN	36..410	CDD:238101	94/424 (22%)
Serpina12	NP_620180.2	alpha-1-antitrypsin_like	51..408	CDD:239011	95/426 (22%)
Serpina12	NP_620180.2	Reactive center loop. /evidence=ECO:0000250\|UniProtKB:Q8IW75	364..382		4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910