DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn77Bc and Serpind1

DIOPT Version :9

Sequence 1:	NP_001262103.1	Gene:	Spn77Bc / 40236	FlyBaseID:	FBgn0036970	Length:	416	Species:	Drosophila melanogaster
Sequence 2:	NP_001317976.1	Gene:	Serpind1 / 15160	MGIID:	96051	Length:	478	Species:	Mus musculus

Alignment Length:	394	Identity:	88/394 - (22%)
Similarity:	161/394 - (40%)	Gaps:	34/394 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KSLLQKMTDARLQFALNLLQ-MESTHLNLENFAMTPFSTWSLMIMFYEGAEGTTLKQIRDVLAIY 90
            ||.:|::.....:||.||.: ::......:|..:.|....:.|.|...|..|.|.:::..||. :
Mouse    99 KSRIQRLNILNAKFAFNLYRVLKDQATTSDNLFIAPVGISTAMGMISLGLRGETHEEVHSVLH-F 162

  Fly    91 VDYPTLRRWYEDVRAYHYLNSENTKLFSLRYAY-YDDVGDLELVKGYNSVVLEGVGEGNVVLRE- 153
            .|:......||....::.......:||...:.| ...|..|.:.|.:  .:.|   :....:||
Mouse   163 RDFVNASSKYEVTTIHNLFRKLTHRLFRRNFGYTLRSVNGLYIQKQF--PIRE---DFKAAMREF 222

  Fly   154 --GRPRGVDFDQGASII-INDDIDKASHAKIFSSYSRRSFNSTVTVLGITVSYFKAKWKYPFDKS 215
              ...:..:|...|.|. .|:.|.|.:...|  ..:..:.:....:|.:...|||..|...|...
Mouse   223 YFAEAQEANFPDPAFISKANNHILKLTKGLI--KEALENIDPATQMLILNCIYFKGTWVNKFPVE 285

  Fly   216 QTKVEQFYNAGGSPAGKVEMMVQTGKYAYVNNVKGLQADVLELPF--GEHELVMIVILPKPSQRV 278
            .|....| ........||.||...|.:...|: :.|..|:|:|.:  |   :.|::::|:....:
Mouse   286 MTHNHNF-RLNEREVVKVSMMQTKGNFLAAND-QELDCDILQLEYVGG---ISMLIVVPRKLSGM 345

  Fly   279 SLVLKQLKNLGLHRLLEELEASKNESDVEVKLPKFDTRSVLSLEDTVYEAGLTDLRNEFADLGRM 343
            ..:..||    ..:::|..:.|......||.||||......:|.:.:...|:|.|.|:..::..:
Mouse   346 KTLEAQL----TPQVVERWQKSMTNRTREVLLPKFKLEKNYNLVEVLKSMGITKLFNKNGNMSGI 406

  Fly   344 LIPTGDRGAYLSLYHQFARIVVDEEGLPNAVPQKSSG----TNNIKFHINRPFAYLVLQRTHKLL 404
                .|:...:.|:...:.|.|:||| ..|....:.|    :..::|.::|||.:||.:.....|
Mouse   407 ----SDQRIAIDLFKHQSTITVNEEG-TQAAAVTTVGFMPLSTQVRFTVDRPFLFLVYEHRTSCL 466

  Fly   405 IHSG 408
            :..|
Mouse   467 LFMG 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Bc	NP_001262103.1	SERPIN	36..410	CDD:238101	85/385 (22%)
Serpind1	NP_001317976.1	HCII	43..476	CDD:239002	88/394 (22%)
		2 X 11 AA approximate repeats, Asp/Glu-rich (acidic) (hirudin-like)	54..78
		Glycosaminoglycan-binding site. /evidence=ECO:0000250	171..191		4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920