Protein Alignment Spn77Bc and SERPINA3

DIOPT Version :10

• Sequence 1: NP_649207.1
• Gene: Spn77Bc / 40236
• FlyBaseID: FBgn0036970
• Length: 416
• Species: Drosophila melanogaster
• Sequence 2: NP_001076.2
• Gene: SERPINA3 / 12
• HGNCID: 16
• Length: 423
• Species: Homo sapiens
• Alignment Length: 430
• Identity: 94/430 - (21%)
• Similarity: 165/430 - (38%)
• Gaps: 73/430 - (16%)

  Fly     6 LGLFGMVLSLRAHICA-------NTVDTKSLLQKMTD-----------ARLQFALNLLQMESTHL 52
            |||      |.|..|.       :.:|.::|.|:..|           |.:.||.:|.:......
Human    10 LGL------LAAGFCPAVLCHPNSPLDEENLTQENQDRGTHVDLGLASANVDFAFSLYKQLVLKA 68

  Fly    53 NLENFAMTPFSTWSLMIMFYEGAEGTTLKQIRDVLAIYVDYPTLRRWYEDVRAYHYLNSENTKLF 117
            ..:|...:|.|..:.:.....||..|||.:|...|...:...:....::..:  |.|.:.|....
Human    69 PDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIHQSFQ--HLLRTLNQSSD 131

  Fly   118 SLRYAYYDDVGDLELVKGYNSVVLEGVGEGNVVLREGRPRGVDFDQGASI--IINDDIDKASHAK 180
            .|:.:    :|:...||...| :|:...|....|........||...|:.  :|||.:...:..|
Human   132 ELQLS----MGNAMFVKEQLS-LLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGK 191

  Fly   181 IFSSYSRRSFNSTVTVLGITVSYFKAKWKYPFDKSQTKVEQFYNAGGSPAGKVEMMVQTGKYAYV 245
            |....  :..:|...::.:...:|||||:.|||...|...:||     .:.|..:||......::
Human   192 ITDLI--KDLDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFY-----LSKKKWVMVPMMSLHHL 249

  Fly   246 N----NVKGLQADVLELPFGEHELVMIVILPKPSQRVSLVLKQLKNLGLHRLLEELEASKNESDV 306
            .    ..:.|...|:||.:..:...:. |||...:     :::::.:.|...|:....|....::
Human   250 TIPYFRDEELSCTVVELKYTGNASALF-ILPDQDK-----MEEVEAMLLPETLKRWRDSLEFREI 308

  Fly   307 -EVKLPKFDTRSVLSLEDTVYEAGLTDLRNEFADLGRMLIPTGDRGAYLSLYHQFARIVVDEEGL 370
             |:.||||......:|.|.:.:.|:.:.....|||..:   ||.|...:|.....|.:.|.|||
Human   309 GELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGI---TGARNLAVSQVVHKAVLDVFEEG- 369

  Fly   371 PNAVPQKSSGTNNIKF-------------HINRPFAYLVL 397
                 .::|....:|.             ..||||..:::
Human   370 -----TEASAATAVKITLLSALVETRTIVRFNRPFLMIIV 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Bc	NP_649207.1	serpin	33..412	CDD:476815	85/396 (21%)
SERPINA3	NP_001076.2	serpinA3_A1AC	40..421	CDD:381019	85/394 (22%)
		RCL	369..394		3/30 (10%)
		O-glycosylated at one site	381..389		0/7 (0%)