Protein Alignment Spn77Bb and SERPINB3

DIOPT Version :10

• Sequence 1: NP_649206.1
• Gene: Spn77Bb / 40235
• FlyBaseID: FBgn0036969
• Length: 362
• Species: Drosophila melanogaster
• Sequence 2: NP_008850.1
• Gene: SERPINB3 / 6317
• HGNCID: 10569
• Length: 390
• Species: Homo sapiens
• Alignment Length: 391
• Identity: 103/391 - (26%)
• Similarity: 160/391 - (40%)
• Gaps: 86/391 - (21%)

  Fly    10 GMVLMIMFYEGAEGYTVNELRDVLGI--------------YVD---------YPTLRRWYEDVRA 51
            ||||:     ||:..|..:::.||..              :||         ...|..:.:...|
Human    39 GMVLL-----GAKDNTAQQIKKVLHFDQVTENTTGKAATYHVDRSGNVHHQFQKLLTEFNKSTDA 98

  Fly    52 Y-----HYLNSENTKLFSLRYAYYDDVGDLELVKGYNSVVLEGVGEGNVVLREGRPRGVDFDQGA 111
            |     :.|..|.|.||...|        |:.:|.:....:|.|...|.. .|.|.:
Human    99 YELKIANKLFGEKTYLFLQEY--------LDAIKKFYQTSVESVDFANAP-EESRKK-------- 146

  Fly   112 SIIINDDIDKASHAKIFSSYSRRSFNSTVTVLGITVSYFKAKWKYPFDKSQTKVEQFYNDGGSPA 176
               ||..::..::.||.:.....:..|..|::.:...|||.:|:..|:|..||.|:|:.:..: .
Human   147 ---INSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKFWPNKNT-Y 207

  Fly   177 GKVEMMVQTGKYAYVNNVKGLQADVLELPFGEHELVMIVLLPKSSQGVNLVLYQLKNLGLHRLLE 241
            ..::||.|...:.:. :::.:||.|||:|:...:|.||||||....            ||.:|.|
Human   208 KSIQMMRQYTSFHFA-SLEDVQAKVLEIPYKGKDLSMIVLLPNEID------------GLQKLEE 259

  Fly   242 KLEASK----------NETDVEVKLPKFDTRSVLSLEDTVYDAGLTDLRNDFADLDKLLIAIGHR 296
            ||.|.|          .||.|::.||:|.......|:||:...|:.|:.|..|||..:   .|.|
Human   260 KLTAEKLMEWTSLQNMRETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFNGDADLSGM---TGSR 321

  Fly   297 GACLTLYHQFARIVVDEEGLPNAVPQ------KSSGKNNIKFHVNRPFAYLVLQKKHKLLIHSGV 355
            |..|:.....|.:.|.|||...|...      .|....|.:||.|.||.:.:.|.|...::..|.
Human   322 GLVLSGVLHKAFVEVTEEGAEAAAATAVVGFGSSPTSTNEEFHCNHPFLFFIRQNKTNSILFYGR 386

  Fly   356 F 356
            |
Human   387 F 387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Bb	NP_649206.1	serpin	13..358	CDD:476815	100/388 (26%)
SERPINB3	NP_008850.1	serpinB3_B4_SCCA1_2	1..390	CDD:381030	103/391 (26%)