Protein Alignment Spn77Bb and SERPINA1

DIOPT Version :10

• Sequence 1: NP_649206.1
• Gene: Spn77Bb / 40235
• FlyBaseID: FBgn0036969
• Length: 362
• Species: Drosophila melanogaster
• Sequence 2: NP_000286.3
• Gene: SERPINA1 / 5265
• HGNCID: 8941
• Length: 418
• Species: Homo sapiens
• Alignment Length: 401
• Identity: 85/401 - (21%)
• Similarity: 148/401 - (36%)
• Gaps: 117/401 - (29%)

  Fly    38 DYPTLRRWYEDVRAY---------HYLNSEN---------TKLFSLRYAYYDDVGDLELVKGYN- 83
            |:||..:...::..:         |..||.|         |....|......|..| |:::|.|
Human    43 DHPTFNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHD-EILEGLNF 106

  Fly    84 -------SVVLEGVGE---------GNVVLREGRPRGVDFDQGASII------------------ 114
                   :.:.||..|         ..:.|..|  .|:...:|..::
Human   107 NLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTG--NGLFLSEGLKLVDKFLEDVKKLYHSEAFTV 169

  Fly   115 -----------INDDIDKASHAKIFSSYSRRSFNSTVTVLGITVSYFKAKWKYPFDKSQTKVEQF 168
                       |||.::|.:..||........ ..||..| :...:||.||:.||:...|:.|.|
Human   170 NFGDTEEAKKQINDYVEKGTQGKIVDLVKELD-RDTVFAL-VNYIFFKGKWERPFEVKDTEEEDF 232

  Fly   169 YNDGGSPAGKVEMMVQTGKYAYVNNVKGLQADVLELPF-GEHELVMIVLLPKSSQGVNLVLYQLK 232
            :.|..:.. ||.||.:.|.: .:.:.|.|.:.||.:.: |  ....|..||...:     |..|:
Human   233 HVDQVTTV-KVPMMKRLGMF-NIQHCKKLSSWVLLMKYLG--NATAIFFLPDEGK-----LQHLE 288

  Fly   233 NLGLHRLLEKLEASKNETDVEVKLPKFDTRSVLSLEDTVYDAGLTDLRNDFADLD--------KL 289
            |...|.::.|...:::.....:.|||........|:..:...|:|.:.::.|||.        ||
Human   289 NELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKL 353

  Fly   290 LIAIGHRGACLTLYHQFARIVVDEEG-----------LPNAVPQKSSGKNNIKFHVNRPFAYLVL 343
            ..|: |:          |.:.:||:|           :|.::|.:      :||  |:||.:|::
Human   354 SKAV-HK----------AVLTIDEKGTEAAGAMFLEAIPMSIPPE------VKF--NKPFVFLMI 399

  Fly   344 QKKHKLLIHSG 354
            ::..|..:..|
Human   400 EQNTKSPLFMG 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Bb	NP_649206.1	serpin	13..358	CDD:476815	85/401 (21%)
SERPINA1	NP_000286.3	serpinA1_A1AT	50..417	CDD:381012	82/394 (21%)
		RCL	368..392		5/31 (16%)