DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn77Ba and Serpina12

DIOPT Version :9

Sequence 1:	NP_001287128.1	Gene:	Spn77Ba / 40234	FlyBaseID:	FBgn0262057	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_080811.1	Gene:	Serpina12 / 68054	MGIID:	1915304	Length:	413	Species:	Mus musculus

Alignment Length:	430	Identity:	108/430 - (25%)
Similarity:	193/430 - (44%)	Gaps:	50/430 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LSVGNPLTAFTAPTAFQSGVSHIQSMRSNFDTDVLVSISQGVQDFALDLLQRISVEVEKANKDFM 99
            |:|...|....||..:.|.| .:|..|...|..   .:::...:|...||||::....:.|  ..
Mouse    15 LTVKGLLQDRDAPDMYDSPV-RVQEWRGKKDAR---QLARHNMEFGFKLLQRLASNSPQGN--IF 73

  Fly   100 ISPFSVWSLLVLLYEGSEGETRNQLKKSLRI-NVEDEKLRGAYKVWSSFLNITTSTIEVATLQAI 163
            :||.|:.:...:|..|::..|..::::.... .:.:..:..|:......||..|...::....|:
Mouse    74 LSPLSISTAFSMLSLGAQNSTLEEIREGFNFKEMSNWDVHAAFHYLLHKLNQETEDTKMNLGNAL 138

  Fly   164 YTGKGYPIKNNYRDAIQNYNVQPMEVDFYSPDSVIQINEDTNRTTRGLIPYTILPQDVY------ 222
            :..:....:..:.:..:|         .|..|.|:...:|...|.:.:..|  :.|..:
Mouse   139 FMDQKLRPQQRFLNLAKN---------VYDADMVLTNFQDLENTQKDINRY--ISQKTHSRIKNM 192

  Fly   223 ------GAKMFLLSSLYFKGQWKFPFNKTLTREEPFFSESGEVIGKIPMMVQEA--NFAYVSNVE 279
                  |..|.|.:.:||:|:|::.|:...|:||.||.|.|:.: |:|||.|..  :.||.|.
Mouse   193 VKSIDPGTVMILTNYIYFRGRWQYEFDPKQTKEEEFFIEKGKTV-KVPMMFQRGLYDMAYDSQ-- 254

  Fly   280 GLDGYVLELPYGTQDRLAMIVVLPKRGFKLNDVANNLKALGLRPILQRLAAFRNRASEDNEVEVM 344
             |...:||:||  :..:....|||..| ||..:...|:|       ...|.:::..|: ..|:|.
Mouse   255 -LSCTILEIPY--RGNITATFVLPDNG-KLKLLEQGLQA-------DIFAKWKSLLSK-RVVDVW 307

  Fly   345 MPKFVTATDFTLKGVLIQMGIRDLFDENTANLDRMSSGLFAKL--VVHSTKIIVDEQGTTAGAVT 407
            :||...::.:.:|.||.::||..:|:|| .:|.|:||....|:  .||..::.:||:|....|.:
Mouse   308 VPKLRISSTYNMKKVLSRLGISKIFEEN-GDLTRISSHRSLKVGEAVHKAELKMDEKGMEGAAGS 371

  Fly   408 EAALANKATPPKFLLNRPFQYMIVEKATGLLLFAGQVRNP 447
            .|......||....|:|||..||.|.....::|..::.:|
Mouse   372 GAQTLPMETPRHMKLDRPFLMMIYENFMPSMVFLARIYDP 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Ba	NP_001287128.1	SERPIN	75..444	CDD:238101	97/385 (25%)
Serpina12	NP_080811.1	alpha-1-antitrypsin_like	51..408	CDD:239011	97/385 (25%)
Serpina12	NP_080811.1	Reactive center loop. /evidence=ECO:0000250\|UniProtKB:Q8IW75	364..382		4/17 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910