DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn77Ba and SERPINI1

DIOPT Version :9

Sequence 1:	NP_001287128.1	Gene:	Spn77Ba / 40234	FlyBaseID:	FBgn0262057	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001116224.1	Gene:	SERPINI1 / 5274	HGNCID:	8943	Length:	410	Species:	Homo sapiens

Alignment Length:	409	Identity:	107/409 - (26%)
Similarity:	199/409 - (48%)	Gaps:	41/409 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 FDTDVLVSISQG-------VQDFALDLLQRISVEVEKANKDFMISPFSVWSLLVLLYEGSEGETR 121
            |...||.|::.|       :.|.::::..|:....|..|  .:.||.|:...:.::..|::|.|:
Human     7 FSLLVLQSMATGATFPEEAIADLSVNMYNRLRATGEDEN--ILFSPLSIALAMGMMELGAQGSTQ 69

  Fly   122 NQLKKSLRINVEDEKLRGAYKVWSSFLNITTS-----TIEVATLQAIYTGKGYPIKNNYRDAIQN 181
            .:::.|:  ..:..|....:.....|.|:.|:     .:::|  .:::...|:.:...:...::.
Human    70 KEIRHSM--GYDSLKNGEEFSFLKEFSNMVTAKESQYVMKIA--NSLFVQNGFHVNEEFLQMMKK 130

  Fly   182 Y-NVQPMEVDFYSPDSVIQ-INEDTNRTTRGLIPYTILPQDVYGAK-MFLLSSLYFKGQWKFPFN 243
            | |.....|||....:|.. ||:.....|..|:...:.|:|...|. :.|::::||||.||..|.
Human   131 YFNAAVNHVDFSQNVAVANYINKWVENNTNNLVKDLVSPRDFDAATYLALINAVYFKGNWKSQFR 195

  Fly   244 KTLTREEPFFSESGEVIGKIPMMVQEANFAY-----VSNVEGLDGYVLELPYGTQDRLAMIVVLP 303
            ...||...|..:....: :||||.|:..|.|     .||..|....|||:|| ..|.::|::||.
Human   196 PENTRTFSFTKDDESEV-QIPMMYQQGEFYYGEFSDGSNEAGGIYQVLEIPY-EGDEISMMLVLS 258

  Fly   304 KRGFKLNDVANNLKALGLRPILQRLAAFRNRASEDNEVEVMMPKFVTATDFTLKGVLIQMGIRDL 368
            ::...|..:...:||       |.:..:.|...: .:|||.:|:|....:..||.||..:||.::
Human   259 RQEVPLATLEPLVKA-------QLVEEWANSVKK-QKVEVYLPRFTVEQEIDLKDVLKALGITEI 315

  Fly   369 FDENTANLDRMSSG--LFAKLVVHSTKIIVDEQGTTAGAVT-EAALANKAT-PPKFLLNRPFQYM 429
            |.:: |||..:|..  :|....:|.:.:.|:|:|:.|.||: ..|::..|. .|:.:::.||.::
Human   316 FIKD-ANLTGLSDNKEIFLSKAIHKSFLEVNEEGSEAAAVSGMIAISRMAVLYPQVIVDHPFFFL 379

  Fly   430 IVEKATGLLLFAGQVRNPK 448
            |..:.||.:||.|:|.:|:
Human   380 IRNRRTGTILFMGRVMHPE 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Ba	NP_001287128.1	SERPIN	75..444	CDD:238101	101/392 (26%)
SERPINI1	NP_001116224.1	neuroserpin	23..410	CDD:239003	102/393 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930