DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn77Ba and SERPINB6

DIOPT Version :9

Sequence 1:	NP_001287128.1	Gene:	Spn77Ba / 40234	FlyBaseID:	FBgn0262057	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	XP_011512974.1	Gene:	SERPINB6 / 5269	HGNCID:	8950	Length:	454	Species:	Homo sapiens

Alignment Length:	411	Identity:	107/411 - (26%)
Similarity:	189/411 - (45%)	Gaps:	42/411 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 GVSHIQSMRSNFDTDVLVSISQGVQDFALDLLQRISVEVEKANKDFMISPFSVWSLLVLLYEGSE 117
            |:.||:|.       ::..:::....|||:||:.:.   :..:|:...||.|:...|.::|.|::
Human    70 GLLHIKSA-------IMDVLAEANGTFALNLLKTLG---KDNSKNVFFSPMSMSCALAMVYMGAK 124

  Fly   118 GETRNQLKKSLRINVEDEKLRGAYKVWSSFLNITTSTIEVAT------LQAIYTGKGYPIKNNYR 176
            |.|..|:.:.|..|    |..|...:...|.::.|...:..|      ...::..|.....:::|
Human   125 GNTAAQMAQILSFN----KSGGGGDIHQGFQSLLTEVNKTGTQYLLRMANRLFGEKSCDFLSSFR 185

  Fly   177 DAIQN-YNVQPMEVDFYS--PDSVIQINEDTNRTTRGLIPYTILPQDVYG-AKMFLLSSLYFKGQ 237
            |:.|. |..:..|:||.|  ..|...||......|.|.|...:.|..|.. .::.|::::||:|.
Human   186 DSCQKFYQAEMEELDFISAVEKSRKHINTWVAEKTEGKIAELLSPGSVDPLTRLVLVNAVYFRGN 250

  Fly   238 WKFPFNKTLTREEPFFSESGEVIGKIPMMVQEANF--AYVSNVEGLDGYVLELPYGTQDRLAMIV 300
            |...|:|..| ||..|..|......:.||.:::.|  .|:..:   ...:|.|||..:: |.||:
Human   251 WDEQFDKENT-EERLFKVSKNEEKPVQMMFKQSTFKKTYIGEI---FTQILVLPYVGKE-LNMII 310

  Fly   301 VLPKRGFKLNDVANNLKALGLRPILQRLAAF-RNRASEDNEVEVMMPKFVTATDFTLKGVLIQMG 364
            :||       |...:|:.:......::...: |....::.||||.:|:|.....:.::.||..:|
Human   311 MLP-------DETTDLRTVEKELTYEKFVEWTRLDMMDEEEVEVSLPRFKLEESYDMESVLRNLG 368

  Fly   365 IRDLFDENTANLDRMS-SGLFAKLVVHSTKIIVDEQGTTAGAVTEAALANKAT--PPKFLLNRPF 426
            :.|.|:...|:...|| :.|....|||.:.:.|:|:||.|.|.|.|.:..:..  .|:|..:.||
Human   369 MTDAFELGKADFSGMSQTDLSLSKVVHKSFVEVNEEGTEAAAATAAIMMMRCARFVPRFCADHPF 433

  Fly   427 QYMIVEKATGLLLFAGQVRNP 447
            .:.|....|..:||.|:..:|
Human   434 LFFIQHSKTNGILFCGRFSSP 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Ba	NP_001287128.1	SERPIN	75..444	CDD:238101	102/384 (27%)
SERPINB6	XP_011512974.1	PAI-2	82..454	CDD:239013	102/390 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG57242
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.030