DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn77Ba and Serpinh1

DIOPT Version :9

Sequence 1:	NP_001287128.1	Gene:	Spn77Ba / 40234	FlyBaseID:	FBgn0262057	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_058869.2	Gene:	Serpinh1 / 29345	RGDID:	69302	Length:	417	Species:	Rattus norvegicus

Alignment Length:	452	Identity:	110/452 - (24%)
Similarity:	195/452 - (43%)	Gaps:	63/452 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLLGAIFLCSADPQNNQAPLQLSVGNPLTAFTAPTAFQSGVSHIQSMRSNFDTDVLVSISQGVQD 78
            ||||.:.|.:       ..|...|..|:.| |||     |.:...|.::.    .|...|.|:
  Rat     4 LLLGTLCLLA-------VALAAEVKKPVEA-TAP-----GTAEKLSSKAT----TLAERSTGL-- 49

  Fly    79 FALDLLQRISVEVEKANKDFMISPFSVWSLLVLLYEGSEGETRNQLKKSLRINVEDEKLR----- 138
             |..|.|  ::..::|.::.::||..|.|.|.|:..|.:..|.:|.|..|    ..||||
  Rat    50 -AFSLYQ--AMAKDQAVENILLSPLVVASSLGLVSLGGKATTASQAKAVL----SAEKLRDEEVH 107

  Fly   139 -GAYKVWSSFLNITTSTIEVATLQAIYTGKGYPIKNNY-RDAIQNYNVQPMEVDFYSPDSVIQ-I 200
             |..::..|..|.|...:.......:|........::: |.:.|:||.:..:::|....|.:| |
  Rat   108 TGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSI 172

  Fly   201 NEDTNRTTRGLIPYTILPQDVY---GAKMFLLSSLYFKGQWKFPFNKTLTREEPFFSESGEVIGK 262
            ||..::||.|.:|.  :.:||.   ||  .|:::::||..|...|:..:.....|.......:|
  Rat   173 NEWASQTTDGKLPE--VTKDVERTDGA--LLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVG- 232

  Fly   263 IPMMVQEANFAYVSN-VEGLDGYVLELPYGTQDRLAMIVVLPKRGFKLNDVANNLKALGLRPILQ 326
            :.||.:...:.|..: .|.|.  ::|:|. .....::|:::|.....|..:...|....|:..:.
  Rat   233 VTMMHRTGLYNYYDDEKEKLQ--LVEMPL-AHKLSSLIILMPHHVEPLERLEKLLTKEQLKTWMG 294

  Fly   327 RLAAFRNRASEDNEVEVMMPKFVTATDFTLKGVLIQMGIRDLFDENTANLDRMS--SGLFAKLVV 389
            ::        :...|.:.:||.|......|:..|..:|:.:..|:|.|:|.|||  ..|:...|.
  Rat   295 KM--------QKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVF 351

  Fly   390 HSTKIIVDEQGTTAGAVTEAALANK---ATPPKFLLNRPFQYMIVEKATGLLLFAGQVRNPK 448
            |:|....|    |.|...:..:..:   .:|..|..:.||.:::.:..:|.|||.|::..||
  Rat   352 HATAFEWD----TEGNPFDQDIYGREELRSPKLFYADHPFIFLVRDNQSGSLLFIGRLVRPK 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Ba	NP_001287128.1	SERPIN	75..444	CDD:238101	92/385 (24%)
Serpinh1	NP_058869.2	serpinH1_CBP1	35..416	CDD:381003	97/408 (24%)
Serpinh1	NP_058869.2	Prevents secretion from ER. /evidence=ECO:0000305	414..417
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110