DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn77Ba and Serpine1

DIOPT Version :9

Sequence 1:	NP_001287128.1	Gene:	Spn77Ba / 40234	FlyBaseID:	FBgn0262057	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_036752.2	Gene:	Serpine1 / 24617	RGDID:	3249	Length:	402	Species:	Rattus norvegicus

Alignment Length:	462	Identity:	112/462 - (24%)
Similarity:	195/462 - (42%)	Gaps:	77/462 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGKIADCLMLWIPLLLGAIFLCSADPQNNQAPLQLSVGNPLTAFTAPTAFQSGVSHIQSMRSNFD 65
            |.....||.|.:.|:.|..|                 .:||..           ||.....:||.
  Rat     3 MSSALTCLTLGLVLVFGKGF-----------------ASPLPE-----------SHTAQQATNFG 39

  Fly    66 TDVLVSISQGVQDFALDLLQRISVEVEKANKDFMISPFSVWSLLVLLYEGSEGETRNQLKKSLRI 130
            ..|...:.|..:|                 ::.:.||:.|.|:|.:|...:.|:||.|::.::..
  Rat    40 VKVFQHVVQASKD-----------------RNVVFSPYGVSSVLAMLQLTTAGKTRQQIQDAMGF 87

  Fly   131 NVEDEKLRGAYKVWSSFLNITTSTIEVATLQAIYTGKGYPIKNNYR-DAIQNYNVQPMEVDFYSP 194
            |:.:.....|.:..|..|..:.:..|::|..||:..:...:...:. ...:.:.....:|||...
  Rat    88 NISERGTAPALRKLSKELMGSWNKNEISTADAIFVQRDLELVQGFMPHFFKLFRTTVKQVDFSEM 152

  Fly   195 DSV-IQINEDTNRTTRGLIPYTILPQDVYG--AKMFLLSSLYFKGQWKFPFNKTLTREEPFFSES 256
            :.. ..||:...|.|:|:|. .:|.:....  .::.|:::|||.||||.||.:..|.:..|....
  Rat   153 ERARFIINDWVERHTKGMIS-DLLAKGAVNELTRLVLVNALYFNGQWKTPFLEASTHQRLFHKSD 216

  Fly   257 GEVIGKIPMMVQEANFAYV--SNVEGLDGYVLELPYGTQDRLAMIVVLP-KRGFKLNDVANNLKA 318
            |..| .:|||.|...|.|.  :..:|.:..:||||| ..:.|:|.:..| ::...|:.:.|.|.|
  Rat   217 GSTI-SVPMMAQNNKFNYTEFTTPDGHEYDILELPY-HGETLSMFIAAPFEKDVPLSAITNILDA 279

  Fly   319 LGLR------PILQRLAAFRNRASEDNEVEVMMPKFVTATDFTLKGVLIQMGIRDLFDENTANLD 377
            ..:|      ..|.||              :::|||...|:..|:|.|.::|:.|:|....|:..
  Rat   280 ELIRQWKSNMTRLPRL--------------LILPKFSLETEVDLRGPLEKLGMTDIFSSTQADFT 330

  Fly   378 RMS--SGLFAKLVVHSTKIIVDEQGTTAGAVTEAALANKATPPKFLLNRPFQYMIVEKATGLLLF 440
            .:|  ..|.....:...||.|:|.||.|.:.|...::.:..|.:.:|:|.|.:::....|..:||
  Rat   331 SLSDQEQLSVAQALQKVKIEVNESGTVASSSTAILVSARMAPTEMVLDRSFLFVVRHNPTETILF 395

  Fly   441 AGQVRNP 447
            .||:..|
  Rat   396 MGQLMEP 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Ba	NP_001287128.1	SERPIN	75..444	CDD:238101	95/383 (25%)
Serpine1	NP_036752.2	serpin	29..402	CDD:422956	102/406 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556621at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920