DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn77Ba and Serpina10

DIOPT Version :9

Sequence 1:	NP_001287128.1	Gene:	Spn77Ba / 40234	FlyBaseID:	FBgn0262057	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_659083.2	Gene:	Serpina10 / 217847	MGIID:	2667725	Length:	448	Species:	Mus musculus

Alignment Length:	398	Identity:	105/398 - (26%)
Similarity:	187/398 - (46%)	Gaps:	53/398 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 ISQGVQDFALDLLQRISVEVEKANKDFMISPFSVWSLLVLLYEGSEGETRNQLKKSLRINVEDEK 136
            :|.....|..:||::||:   :.:.:.:.|||.:...:|.|..|::|||:.|::..|.:....:.
Mouse    79 LSNETSSFGFNLLRKISM---RHDGNVIFSPFGLSVAMVNLMLGTKGETKVQIENGLNLQALSQA 140

  Fly   137 ----LRGAYK----VWSSFLNITTSTIEVATLQAIYTGKGYPIKNNYRDAIQNYNVQPMEVDFYS 193
                |...:|    .:||..::..|....|     :..|.:.||..|.:..:.|    .::::
Mouse   141 GPLILPALFKKVKETFSSNRDLGLSQGSFA-----FIHKDFDIKETYFNLSKKY----FDIEY-- 194

  Fly   194 PDSVIQINEDTNRTTRGLIPYTILPQDVYG------------AKMFLLSSLYFKGQWKFPFNKTL 246
                :.||...:...||||.:.|: ::..|            .|:.|:..:.|||:|..||:.:.
Mouse   195 ----VSINFQNSSQARGLINHCIV-KETEGKIPKLFDEINPETKLILVDYVLFKGKWLTPFDPSF 254

  Fly   247 TREEPFFSESGEVIGKIPMMVQEANFAYVSNVEGLDGYVLELPYGTQDRLAMIVVLPKRGFKLND 311
            |..:.|..:....| |:|||.:|.||....: :....::|:|||  |....|:|||.::......
Mouse   255 TEADTFHLDKYRAI-KVPMMYREGNFTSTFD-KKFRCHILKLPY--QGNATMLVVLMEKTGDYLA 315

  Fly   312 VANNLKALGLRPILQRLAAFRNRASEDNEVEVMMPKFVTATDFTLKGVLIQMGIRDLFDENT--A 374
            :.:.|....:...||.:        :..::||..|||.....:.:..:|.|||||.||..:.  :
Mouse   316 LEDYLTVDLVETWLQNM--------KTRKMEVFFPKFKLNQRYEMHELLKQMGIRRLFSTSADLS 372

  Fly   375 NLDRMSSGLFAKLVVHSTKIIVDEQGTTAGAVTEAALANKATPPKFLLNRPFQYMIVEKATGLLL 439
            .|..|:..|....|:..:.:.|||:||.|.:.|.:.:...:.||...:||||.::|.|:.:.:||
Mouse   373 ELSAMARNLQVSRVLQQSVLEVDERGTEAVSGTLSEIIAYSMPPAIKVNRPFHFIIYEEMSRMLL 437

  Fly   440 FAGQVRNP 447
            |.|:|.||
Mouse   438 FLGRVVNP 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Ba	NP_001287128.1	SERPIN	75..444	CDD:238101	101/390 (26%)
Serpina10	NP_659083.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..70
		SERPIN	78..442	CDD:294093	102/393 (26%)
		Heparin-binding. /evidence=ECO:0000250	140..157		2/16 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010