DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn77Ba and Serpina1d

DIOPT Version :9

Sequence 1:	NP_001287128.1	Gene:	Spn77Ba / 40234	FlyBaseID:	FBgn0262057	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_033272.1	Gene:	Serpina1d / 20703	MGIID:	891968	Length:	413	Species:	Mus musculus

Alignment Length:	414	Identity:	103/414 - (24%)
Similarity:	186/414 - (44%)	Gaps:	57/414 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 QSGVSHIQSMRSNFDTDVLVSISQGVQDFALDLLQRISVEVEKAN-KDFMISPFSVWSLLVLLYE 114
            ||..||              .|:..:.||||.|.:.:   |.::| .:...||.|:.:...:|..
Mouse    37 QSPASH--------------EIATNLGDFALRLYREL---VHQSNTSNIFFSPVSIATAFAMLSL 84

  Fly   115 GSEGETRNQLKKSLRINVEDEKLRGAYKVWSSF---LNITTSTIEVATLQAIYTGKGYPIKNNYR 176
            ||:|:|..|:.:.|:.|:........:|.:...   ||...|.::::      ||.|..:.|:.:
Mouse    85 GSKGDTHTQILEGLQFNLTQTSEADIHKSFQHLLQTLNRPDSELQLS------TGNGLFVNNDLK 143

  Fly   177 -------DAIQNYNVQPMEVDF-YSPDSVIQINEDTNRTTRGLIPYTI--LPQDVYGAKMFLLSS 231
                   :|..:|..:...|:| .|.::...||:...:.|:|.|...:  |.||...|   |.:.
Mouse   144 LVEKFLEEAKNHYQAEVFSVNFAESEEAKKVINDFVEKGTQGKIVEAVKKLDQDTVFA---LANY 205

  Fly   232 LYFKGQWKFPFNKTLTREEPFFSESGEVIGKIPMMVQEANFAYVSNVEGLDGYVLELPYGTQDRL 296
            :.|||:||.||:...|.|..|..:....: |:|||.. :....|.:...|..:||.:.|.  ...
Mouse   206 ILFKGKWKQPFDPENTEEAEFHVDESTTV-KVPMMTL-SGMLDVHHCSMLSSWVLLMDYA--GNT 266

  Fly   297 AMIVVLPKRGFKLNDVANNLKALGLRPILQRLAAFRNRASEDNEVEVMMPKFVTATDFTLKGVLI 361
            ..:.:||..| |:..:...|.    :.::.:....|.|    ::.::.:|:...:.::.||.::.
Mouse   267 TAVFLLPDDG-KMQHLEQTLN----KELISQFLLNRRR----SDAQIHIPRLSISGNYNLKTLMS 322

  Fly   362 QMGIRDLFDENTANLDRM---SSGLFAKLVVHSTKIIVDEQGTTAGAVTEAALANKATPPKFLLN 423
            .:||..:|: |.|:|..:   ::.|.....||...:.:||.||.|.|.|...:|..:.||....:
Mouse   323 PLGITRIFN-NGADLSGITEENAPLKLSKAVHKAVLTIDETGTEAAAATVLQVATYSMPPIVRFD 386

  Fly   424 RPFQYMIVEKATGLLLFAGQVRNP 447
            .||.::|.|:.|...:|.|:|.:|
Mouse   387 HPFLFIIFEEHTQSPIFVGKVVDP 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Ba	NP_001287128.1	SERPIN	75..444	CDD:238101	96/385 (25%)
Serpina1d	NP_033272.1	SERPIN	53..410	CDD:214513	94/382 (25%)
Serpina1d	NP_033272.1	RCL	368..387		5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910