Protein Alignment Spn77Ba and SERPINB1

DIOPT Version :10

• Sequence 1: NP_649205.3
• Gene: Spn77Ba / 40234
• FlyBaseID: FBgn0262057
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_109591.1
• Gene: SERPINB1 / 1992
• HGNCID: 3311
• Length: 379
• Species: Homo sapiens
• Alignment Length: 383
• Identity: 113/383 - (29%)
• Similarity: 183/383 - (47%)
• Gaps: 28/383 - (7%)

  Fly    79 FALDLLQRISVEVEKANKDFMISPFSVWSLLVLLYEGSEGETRNQLKKSLRINVEDEKLRGAYKV 143
            |||||...:|......|  ..|||||:.|.:.:::.|:.|.|..||.|:...|..:| :...::.
Human    11 FALDLFLALSENNPAGN--IFISPFSISSAMAMVFLGTRGNTAAQLSKTFHFNTVEE-VHSRFQS 72

  Fly   144 WSSFLNITTSTIEVATLQAIYTGKGYPIKNNYRDAIQ-NYNVQPMEVDFY--SPDSVIQINEDTN 205
            .::.:|...::..:.....:|..|.|.....:..:.| .|......|||.  |.|:...||:...
Human    73 LNADINKRGASYILKLANRLYGEKTYNFLPEFLVSTQKTYGADLASVDFQHASEDARKTINQWVK 137

  Fly   206 RTTRGLIPYTILPQDVYG-AKMFLLSSLYFKGQWKFPFNKTLTREEPFFSESGEVIGK-----IP 264
            ..|.|.||..:....|.. .|:.|::::||||.||..|.|..|...||      .:.|     :.
Human   138 GQTEGKIPELLASGMVDNMTKLVLVNAIYFKGNWKDKFMKEATTNAPF------RLNKKDRKTVK 196

  Fly   265 MMVQEANFAYVSNVEGLDGYVLELPYGTQDRLAMIVVLPKRGFKLNDVANNLKALGLRPILQRLA 329
            ||.|:..||| ..:|.|...||||||..:: |:|:::||.   .:.|.:..||.:..:..|::|.
Human   197 MMYQKKKFAY-GYIEDLKCRVLELPYQGEE-LSMVILLPD---DIEDESTGLKKIEEQLTLEKLH 256

  Fly   330 AFRNRASED-NEVEVMMPKFVTATDFTLKGVLIQMGIRDLFDENTANLDRMSSG--LFAKLVVHS 391
            .:....:.| .||.|.:|:|.....:||...|.::|::|||:.:.|:|..||..  :|...:||.
Human   257 EWTKPENLDFIEVNVSLPRFKLEESYTLNSDLARLGVQDLFNSSKADLSGMSGARDIFISKIVHK 321

  Fly   392 TKIIVDEQGTTAGAVTE--AALANKATPPKFLLNRPFQYMIVEKATGLLLFAGQVRNP 447
            :.:.|:|:||.|.|.|.  |..........|..:.||.:.|...::|.:||.|:..:|
Human   322 SFVEVNEEGTEAAAATAGIATFCMLMPEENFTADHPFLFFIRHNSSGSILFLGRFSSP 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Ba	NP_649205.3	serpin77Ba-like_insects	72..447	CDD:381062	112/381 (29%)
SERPINB1	NP_109591.1	serpinB1_LEI	1..379	CDD:381028	112/381 (29%)
		CARD-binding motif (CBM). /evidence=ECO:0000269|PubMed:30692621	351..379		8/27 (30%)