DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn77Ba and AGT

DIOPT Version :9

Sequence 1:	NP_001287128.1	Gene:	Spn77Ba / 40234	FlyBaseID:	FBgn0262057	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001369746.2	Gene:	AGT / 183	HGNCID:	333	Length:	476	Species:	Homo sapiens

Alignment Length:	498	Identity:	98/498 - (19%)
Similarity:	196/498 - (39%)	Gaps:	96/498 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CLMLWIPLLLG-AIFLCSADP-----QNNQAPLQLSVGN------------PLTAFTAPTAFQSG 53
            ||:.|..|..| .:::   .|     .|.....||:..|            |:.|.|:|...::.
Human    14 CLLAWAGLAAGDRVYI---HPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDEKAL 75

  Fly    54 VSHIQSMRSNFDT-DVLVSISQGVQDFALDLLQRISVEVEKANKDF--------MISPFSVWSLL 109
            ...:..:.:..|| |.|.:...|:      |...:...:...:.:.        ::||.:|:..|
Human    76 QDQLVLVAAKLDTEDKLRAAMVGM------LANFLGFRIYGMHSELWGVVHGATVLSPTAVFGTL 134

  Fly   110 VLLYEGSEGETRNQLKKSLRINVEDEKLRG---AYKVWSSFLNI-----------TTSTIEVATL 160
            ..||.|:...|.::|:..|.:..:|:....   |:||.|:...:           :.:.:.::|:
Human   135 ASLYLGALDHTADRLQAILGVPWKDKNCTSRLDAHKVLSALQAVQGLLVAQGRADSQAQLLLSTV 199

  Fly   161 QAIYTGKGYPIKNNYRDAIQNYN--VQPMEVDFYSPD-SVIQINEDTNRTTRGLIPYTILPQDVY 222
            ..::|..|..:|..:...:..|.  |.|..:||...| :..:|:......|......:::...|.
Human   200 VGVFTAPGLHLKQPFVQGLALYTPVVLPRSLDFTELDVAAEKIDRFMQAVTGWKTGCSLMGASVD 264

  Fly   223 GAKMFLLSSLYFKGQWKFPFNKTLTREEPFFSESGEVIGKIPMMVQEANFAYVSNVEGLDGY-VL 286
            ....| .:.::|:|:.| .|:.....:|.:...|..|  .:||:.....|.:.|:::  |.: |.
Human   265 STLAF-NTYVHFQGKMK-GFSLLAEPQEFWVDNSTSV--SVPMLSGMGTFQHWSDIQ--DNFSVT 323

  Fly   287 ELPYGTQDRLAMIVVLPKRGFKLNDV---------ANNLKALGLRPILQRLAAFRNRASEDNEVE 342
            ::|:  .:...::::.|.....|:.|         .|.:|.|..|.|                 .
Human   324 QVPF--TESACLLLIQPHYASDLDKVEGLTFQQNSLNWMKKLSPRTI-----------------H 369

  Fly   343 VMMPKFVTATDFTLKGVLIQMGIRDLFDENTANLDRMSSG-LFAKLVVHST--KIIVDEQGTTAG 404
            :.||:.|....:.|:.:|.|..:..:. ....||.::|:. :....|::|.  ::..||:..|
Human   370 LTMPQLVLQGSYDLQDLLAQAELPAIL-HTELNLQKLSNDRIRVGEVLNSIFFELEADEREPT-- 431

  Fly   405 AVTEAALANKATPPKFLLNRPFQYMIVEKATGLLLFAGQVRNP 447
              ......||....:..|||||.:.:.:::...|.|.|:|.||
Human   432 --ESTQQLNKPEVLEVTLNRPFLFAVYDQSATALHFLGRVANP 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Ba	NP_001287128.1	SERPIN	75..444	CDD:238101	77/406 (19%)
AGT	NP_001369746.2	serpinA8_AGT	28..474	CDD:381010	93/484 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11461
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010