DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spn77Ba and SERPINA3

DIOPT Version :9

Sequence 1:	NP_001287128.1	Gene:	Spn77Ba / 40234	FlyBaseID:	FBgn0262057	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001076.2	Gene:	SERPINA3 / 12	HGNCID:	16	Length:	423	Species:	Homo sapiens

Alignment Length:	404	Identity:	109/404 - (26%)
Similarity:	194/404 - (48%)	Gaps:	42/404 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 TDVLVSISQGVQDFALDLLQRISVEVEKA-NKDFMISPFSVWSLLVLLYEGSEGETRNQLKKSLR 129
            |.|.:.::....|||..|.:::   |.|| :|:.:.||.|:.:.|..|..|:...|..::.|.|:
Human    43 THVDLGLASANVDFAFSLYKQL---VLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLK 104

  Fly   130 INV---EDEKLRGAYKVWSSFLNITTSTIEVATLQAIYTGKGYPIKNNY-RDAIQNYNVQPMEVD 190
            .|:   .:.::..:::.....||.::..::::...|::..:...:.:.: .||.:.|..:....|
Human   105 FNLTETSEAEIHQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATD 169

  Fly   191 FYSPDSVIQ---INEDTNRTTRGLIPYTILPQDVYG-AKMFLLSSLYFKGQWKFPFNKTLTREEP 251
            |  .||...   ||:.....|||.|  |.|.:|:.. ..|.|::.::||.:|:.||:...|.:..
Human   170 F--QDSAAAKKLINDYVKNGTRGKI--TDLIKDLDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSR 230

  Fly   252 FFSESGEVIGKIPMM-VQEANFAYVSNVEGLDGYVLELPYGTQDRLAMIVVLPKRGFKLNDVANN 315
            |:....:.: .:||| :......|..: |.|...|:||.|  ....:.:.:||.:     |....
Human   231 FYLSKKKWV-MVPMMSLHHLTIPYFRD-EELSCTVVELKY--TGNASALFILPDQ-----DKMEE 286

  Fly   316 LKALGLRPILQRLAAFRNRASEDNEV-EVMMPKFVTATDFTLKGVLIQMGIRDLFDENTANLDRM 379
            ::|:.|...|:|   :|: :.|..|: |:.:|||..:.|:.|..:|:|:||.:.| .:.|:|..:
Human   287 VEAMLLPETLKR---WRD-SLEFREIGELYLPKFSISRDYNLNDILLQLGIEEAF-TSKADLSGI 346

  Fly   380 SS--GLFAKLVVHSTKIIVDEQGTTAGAVTE------AALANKATPPKFLLNRPFQYMIVEKATG 436
            :.  .|....|||...:.|.|:||.|.|.|.      :||....|..:|  ||||..:||...|.
Human   347 TGARNLAVSQVVHKAVLDVFEEGTEASAATAVKITLLSALVETRTIVRF--NRPFLMIIVPTDTQ 409

  Fly   437 LLLFAGQVRNPKAA 450
            .:.|..:|.|||.|
Human   410 NIFFMSKVTNPKQA 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spn77Ba	NP_001287128.1	SERPIN	75..444	CDD:238101	102/387 (26%)
SERPINA3	NP_001076.2	serpinA3_A1AC	40..421	CDD:381019	106/400 (27%)
		RCL	369..394		8/24 (33%)
		O-glycosylated at one site	381..389		2/7 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X28
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910