DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaSnap and NAPA

DIOPT Version :9

Sequence 1:	NP_524180.1	Gene:	alphaSnap / 40233	FlyBaseID:	FBgn0250791	Length:	292	Species:	Drosophila melanogaster
Sequence 2:	NP_003818.2	Gene:	NAPA / 8775	HGNCID:	7641	Length:	295	Species:	Homo sapiens

Alignment Length:	295	Identity:	182/295 - (61%)
Similarity:	235/295 - (79%)	Gaps:	6/295 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DN---EQKALQLMAEAEKKLTQQKGFLGSLFGGSNKVEDAIECYQRAGNMFKMSKNWTKAGECFC 64
            ||   |.:|:.|:||||:|:...:.|...|||||:|:|:|.|.|.||.|||||:|||:.||..||
Human     2 DNSGKEAEAMALLAEAERKVKNSQSFFSGLFGGSSKIEEACEIYARAANMFKMAKNWSAAGNAFC 66

  Fly    65 EAATLHARAGSRHDAGTCYVDASNCYKKVDVESAVNCLMKSIDIYTDMGRFTMAAKHHQSIAEMY 129
            :||.||.:..|:|||.||:|||.|.:||.|.:.|:||||::|:|||||||||:|||||.||||:|
Human    67 QAAQLHLQLQSKHDAATCFVDAGNAFKKADPQEAINCLMRAIEIYTDMGRFTIAAKHHISIAEIY 131

  Fly   130 ESDPNNLAKSIQHYEQAADYFKGEESVSSANKCMLKVAQYAAQLEDYEKAISIYEQVAASSLESS 194
            |::..::.|:|.||||:|||:|||||.||||||:||||.|||.||.|:|||.|||||..::::|.
Human   132 ETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAGYAALLEQYQKAIDIYEQVGTNAMDSP 196

  Fly   195 LLKYSAKEYFFRAALCHLSVDLLNAQHAIEKYAQQYPAFQDSREFKLIKVLCENLEEQNIEGFTE 259
            |||||||:|||:|||||..:|:|||:.|::||.:.:|||.||||.||:|.|.|..||||::.:||
Human   197 LLKYSAKDYFFKAALCHFCIDMLNAKLAVQKYEELFPAFSDSRECKLMKKLLEAHEEQNVDSYTE 261

  Fly   260 AVKDYDSISRLDQWYTTILLRIKKA--ADEDPDLR 292
            :||:||||||||||.||:||||||.  .||: |||
Human   262 SVKEYDSISRLDQWLTTMLLRIKKTIQGDEE-DLR 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaSnap	NP_524180.1	SNAP	7..284	CDD:276937	173/276 (63%)
		SNAP	7..284	CDD:291599	173/276 (63%)
		TPR repeat	35..72	CDD:276937	23/36 (64%)
		TPR repeat	76..112	CDD:276937	21/35 (60%)
		TPR repeat	115..152	CDD:276937	22/36 (61%)
		TPR repeat	156..192	CDD:276937	24/35 (69%)
NAPA	NP_003818.2	SNAP	19..287	CDD:405606	168/267 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159299
Domainoid	1	1.000	373	1.000	Domainoid score	I897
eggNOG	1	0.900	-	-		E1_KOG1586
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2839
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2100
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53796
OrthoDB	1	1.010	-	-		D1191204at2759
OrthoFinder	1	1.000	-	-		FOG0001605
OrthoInspector	1	1.000	-	-		otm42282
orthoMCL	1	0.900	-	-		OOG6_101315
Panther	1	1.100	-	-	LDO	PTHR13768
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1307
SonicParanoid	1	1.000	-	-		X1012
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800