DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaSnap and NAPB

DIOPT Version :9

Sequence 1:	NP_524180.1	Gene:	alphaSnap / 40233	FlyBaseID:	FBgn0250791	Length:	292	Species:	Drosophila melanogaster
Sequence 2:	NP_001269947.1	Gene:	NAPB / 63908	HGNCID:	15751	Length:	302	Species:	Homo sapiens

Alignment Length:	301	Identity:	183/301 - (60%)
Similarity:	233/301 - (77%)	Gaps:	11/301 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DN---EQKALQLMAEAEKKLTQQKGFLGSLFGGSNKVEDAIECYQRAGNMFKMSKNW----TKAG 60
            ||   |::|:||||||||::.....||..||||:.::|:|.|.|.||.|||||:|||    :.||
Human     2 DNAGKEREAVQLMAEAEKRVKASHSFLRGLFGGNTRIEEACEMYTRAANMFKMAKNWSVSSSAAG 66

  Fly    61 ECFCEAATLHARAGSRHDAGTCYVDASNCYKKVDVESAVNCLMKSIDIYTDMGRFTMAAKHHQSI 125
            ..||:||.||.:..|:||:.|.:|||.|.|||.|.:.|:|||..:|||||||||||:|||||.:|
Human    67 NAFCQAAKLHMQLQSKHDSATSFVDAGNAYKKADPQEAINCLNAAIDIYTDMGRFTIAAKHHITI 131

  Fly   126 AEMYESDPNNLAKSIQHYEQAADYFKGEESVSSANKCMLKVAQYAAQLEDYEKAISIYEQVAASS 190
            ||:||::..::.|:|.||||:|||:|||||.||||||:||||.||||||.|:|||.|||||.|::
Human   132 AEIYETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAAYAAQLEQYQKAIEIYEQVGANT 196

  Fly   191 LESSLLKYSAKEYFFRAALCHLSVDLLNAQHAIEKYAQQYPAFQDSREFKLIKVLCENLEEQNIE 255
            :::.|||||||:|||:|||||..||.|||:.|:|||.:.:|||.||||.||:|.|.|..||||.|
Human   197 MDNPLLKYSAKDYFFKAALCHFIVDELNAKLALEKYEEMFPAFTDSRECKLLKKLLEAHEEQNSE 261

  Fly   256 GFTEAVKDYDSISRLDQWYTTILLRIKKA----ADEDPDLR 292
            .:|||||::|||||||||.||:||||||:    .:.|.||:
Human   262 AYTEAVKEFDSISRLDQWLTTMLLRIKKSIQGDGEGDGDLK 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaSnap	NP_524180.1	SNAP	7..284	CDD:276937	176/280 (63%)
		SNAP	7..284	CDD:291599	176/280 (63%)
		TPR repeat	35..72	CDD:276937	22/40 (55%)
		TPR repeat	76..112	CDD:276937	20/35 (57%)
		TPR repeat	115..152	CDD:276937	21/36 (58%)
		TPR repeat	156..192	CDD:276937	26/35 (74%)
NAPB	NP_001269947.1	SNAP	9..291	CDD:276937	177/281 (63%)
		TPR repeat	37..78	CDD:276937	22/40 (55%)
		TPR repeat	82..118	CDD:276937	20/35 (57%)
		TPR repeat	121..158	CDD:276937	21/36 (58%)
		TPR repeat	162..198	CDD:276937	26/35 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159300
Domainoid	1	1.000	373	1.000	Domainoid score	I897
eggNOG	1	0.900	-	-		E1_KOG1586
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	376	1.000	Inparanoid score	I2100
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53796
OrthoDB	1	1.010	-	-		D1191204at2759
OrthoFinder	1	1.000	-	-		FOG0001605
OrthoInspector	1	1.000	-	-		otm42282
orthoMCL	1	0.900	-	-		OOG6_101315
Panther	1	1.100	-	-	O	PTHR13768
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1307
SonicParanoid	1	1.000	-	-		X1012
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800