DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaSnap and napaa

DIOPT Version :9

Sequence 1:	NP_524180.1	Gene:	alphaSnap / 40233	FlyBaseID:	FBgn0250791	Length:	292	Species:	Drosophila melanogaster
Sequence 2:	NP_001077030.2	Gene:	napaa / 567306	ZFINID:	ZDB-GENE-060531-160	Length:	295	Species:	Danio rerio

Alignment Length:	289	Identity:	161/289 - (55%)
Similarity:	223/289 - (77%)	Gaps:	1/289 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EQKALQLMAEAEKKLTQQKGFLGSLFGGSNKVEDAIECYQRAGNMFKMSKNWTKAGECFCEAATL 69
            |::|:.:||||:||:.......|:.||.|::||:|.:.|.||.|||||:|||..||:.||:||.|
Zfish     7 EKEAMAIMAEADKKMKTSHSLFGTFFGSSSRVEEACDMYVRAANMFKMAKNWNAAGDAFCKAALL 71

  Fly    70 HARAGSRHDAGTCYVDASNCYKKVDVESAVNCLMKSIDIYTDMGRFTMAAKHHQSIAEMYESDPN 134
            |.:..|:|:|...::||.|.:||.|.:.|:.|..::||||||||||.:|||||.|:||:|||:..
Zfish    72 HLKVDSKHNAAMNFLDAGNAFKKADPQEAIGCFSRAIDIYTDMGRFNIAAKHHISVAEIYESELL 136

  Fly   135 NLAKSIQHYEQAADYFKGEESVSSANKCMLKVAQYAAQLEDYEKAISIYEQVAASSLESSLLKYS 199
            ::.|:|.||||||||:|||||.|:||||:||||.||||||.|:|||.|:||:...|::::||||.
Zfish   137 DIDKAIAHYEQAADYYKGEESTSAANKCLLKVANYAAQLEQYQKAIEIFEQIGTYSMDTTLLKYG 201

  Fly   200 AKEYFFRAALCHLSVDLLNAQHAIEKYAQQYPAFQDSREFKLIKVLCENLEEQNIEGFTEAVKDY 264
            ||::||:|||||..||:||.:.|::||...:|||.|:||.||:|.|.:..:||||:.:.:||:::
Zfish   202 AKDHFFKAALCHFCVDMLNCRLAVQKYEDMFPAFSDARECKLLKKLLDAHDEQNIDAYADAVREF 266

  Fly   265 DSISRLDQWYTTILLRIKKA-ADEDPDLR 292
            |||:|||||.||:||||||. .||:.|||
Zfish   267 DSITRLDQWQTTMLLRIKKTIQDEESDLR 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaSnap	NP_524180.1	SNAP	7..284	CDD:276937	154/276 (56%)
		SNAP	7..284	CDD:291599	154/276 (56%)
		TPR repeat	35..72	CDD:276937	22/36 (61%)
		TPR repeat	76..112	CDD:276937	15/35 (43%)
		TPR repeat	115..152	CDD:276937	22/36 (61%)
		TPR repeat	156..192	CDD:276937	23/35 (66%)
napaa	NP_001077030.2	SNAP	9..288	CDD:291599	155/278 (56%)
		SNAP	9..287	CDD:276937	155/277 (56%)
		TPR repeat	37..74	CDD:276937	22/36 (61%)
		TPR repeat	78..114	CDD:276937	15/35 (43%)
		TPR repeat	114..151	CDD:276809	23/36 (64%)
		TPR repeat	117..154	CDD:276937	22/36 (61%)
		TPR repeat	156..187	CDD:276809	22/30 (73%)
		TPR repeat	158..194	CDD:276937	23/35 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595430
Domainoid	1	1.000	369	1.000	Domainoid score	I863
eggNOG	1	0.900	-	-		E1_KOG1586
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2071
OMA	1	1.010	-	-		QHG53796
OrthoDB	1	1.010	-	-		D1191204at2759
OrthoFinder	1	1.000	-	-		FOG0001605
OrthoInspector	1	1.000	-	-		otm24698
orthoMCL	1	0.900	-	-		OOG6_101315
Panther	1	1.100	-	-	O	PTHR13768
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1012
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770