DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alphaSnap and Napb

DIOPT Version :9

Sequence 1:	NP_524180.1	Gene:	alphaSnap / 40233	FlyBaseID:	FBgn0250791	Length:	292	Species:	Drosophila melanogaster
Sequence 2:	NP_001178895.1	Gene:	Napb / 499903	RGDID:	1589649	Length:	298	Species:	Rattus norvegicus

Alignment Length:	297	Identity:	183/297 - (61%)
Similarity:	233/297 - (78%)	Gaps:	7/297 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DN---EQKALQLMAEAEKKLTQQKGFLGSLFGGSNKVEDAIECYQRAGNMFKMSKNWTKAGECFC 64
            ||   |::|:||||||||::.....||..||||:.::|:|.|.|.||.|||||:|||:.||..||
  Rat     2 DNAGKEREAVQLMAEAEKRVKASHSFLRGLFGGNTRIEEACEMYTRAANMFKMAKNWSAAGNAFC 66

  Fly    65 EAATLHARAGSRHDAGTCYVDASNCYKKVDVESAVNCLMKSIDIYTDMGRFTMAAKHHQSIAEMY 129
            :||.||.:..|:||:.|.:|||.|.|||.|.:.|:|||..:|||||||||||:|||||.:|||:|
  Rat    67 QAAKLHMQLQSKHDSATSFVDAGNAYKKADPQEAINCLNAAIDIYTDMGRFTIAAKHHITIAEIY 131

  Fly   130 ESDPNNLAKSIQHYEQAADYFKGEESVSSANKCMLKVAQYAAQLEDYEKAISIYEQVAASSLESS 194
            |::..::.|:|.||||:|||:|||||.||||||:||||.||||||.|:|||.|||||.|:::::.
  Rat   132 ETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAAYAAQLEQYQKAIEIYEQVGANTMDNP 196

  Fly   195 LLKYSAKEYFFRAALCHLSVDLLNAQHAIEKYAQQYPAFQDSREFKLIKVLCENLEEQNIEGFTE 259
            |||||||:|||:|||||..||.|||:.|:|||.:.:|||.||||.||:|.|.|..||||.|.:||
  Rat   197 LLKYSAKDYFFKAALCHFIVDELNAKLALEKYEEMFPAFTDSRECKLLKKLLEAHEEQNSEAYTE 261

  Fly   260 AVKDYDSISRLDQWYTTILLRIKKA----ADEDPDLR 292
            |||::|||||||||.||:||||||:    .:.|.||:
  Rat   262 AVKEFDSISRLDQWLTTMLLRIKKSIQGDGEGDGDLK 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaSnap	NP_524180.1	SNAP	7..284	CDD:276937	176/276 (64%)
		SNAP	7..284	CDD:291599	176/276 (64%)
		TPR repeat	35..72	CDD:276937	22/36 (61%)
		TPR repeat	76..112	CDD:276937	20/35 (57%)
		TPR repeat	115..152	CDD:276937	21/36 (58%)
		TPR repeat	156..192	CDD:276937	26/35 (74%)
Napb	NP_001178895.1	SNAP	9..287	CDD:276937	177/277 (64%)
		TPR repeat	37..74	CDD:276937	22/36 (61%)
		TPR repeat	78..114	CDD:276937	20/35 (57%)
		TPR repeat	117..154	CDD:276937	21/36 (58%)
		TPR repeat	158..194	CDD:276937	26/35 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353326
Domainoid	1	1.000	376	1.000	Domainoid score	I827
eggNOG	1	0.900	-	-		E1_KOG1586
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	378	1.000	Inparanoid score	I2006
OMA	1	1.010	-	-		QHG53796
OrthoDB	1	1.010	-	-		D1191204at2759
OrthoFinder	1	1.000	-	-		FOG0001605
OrthoInspector	1	1.000	-	-		otm46434
orthoMCL	1	0.900	-	-		OOG6_101315
Panther	1	1.100	-	-	O	PTHR13768
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1012
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770