DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alphaSnap and Napb

DIOPT Version :9

Sequence 1:	NP_524180.1	Gene:	alphaSnap / 40233	FlyBaseID:	FBgn0250791	Length:	292	Species:	Drosophila melanogaster
Sequence 2:	NP_062606.1	Gene:	Napb / 17957	MGIID:	104562	Length:	298	Species:	Mus musculus

Alignment Length:	297	Identity:	183/297 - (61%)
Similarity:	233/297 - (78%)	Gaps:	7/297 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DN---EQKALQLMAEAEKKLTQQKGFLGSLFGGSNKVEDAIECYQRAGNMFKMSKNWTKAGECFC 64
            ||   |::|:||||||||::.....||..||||:.::|:|.|.|.||.|||||:|||:.||..||
Mouse     2 DNAGKEREAVQLMAEAEKRVKASHSFLRGLFGGNTRIEEACEMYTRAANMFKMAKNWSAAGNAFC 66

  Fly    65 EAATLHARAGSRHDAGTCYVDASNCYKKVDVESAVNCLMKSIDIYTDMGRFTMAAKHHQSIAEMY 129
            :||.||.:..|:||:.|.:|||.|.|||.|.:.|:|||..:|||||||||||:|||||.:|||:|
Mouse    67 QAAKLHMQLQSKHDSATSFVDAGNAYKKADPQEAINCLNAAIDIYTDMGRFTIAAKHHITIAEIY 131

  Fly   130 ESDPNNLAKSIQHYEQAADYFKGEESVSSANKCMLKVAQYAAQLEDYEKAISIYEQVAASSLESS 194
            |::..::.|:|.||||:|||:|||||.||||||:||||.||||||.|:|||.|||||.|:::::.
Mouse   132 ETELVDIEKAIAHYEQSADYYKGEESNSSANKCLLKVAAYAAQLEQYQKAIEIYEQVGANTMDNP 196

  Fly   195 LLKYSAKEYFFRAALCHLSVDLLNAQHAIEKYAQQYPAFQDSREFKLIKVLCENLEEQNIEGFTE 259
            |||||||:|||:|||||..||.|||:.|:|||.:.:|||.||||.||:|.|.|..||||.|.:||
Mouse   197 LLKYSAKDYFFKAALCHFIVDELNAKLALEKYEEMFPAFTDSRECKLLKKLLEAHEEQNSEAYTE 261

  Fly   260 AVKDYDSISRLDQWYTTILLRIKKA----ADEDPDLR 292
            |||::|||||||||.||:||||||:    .:.|.||:
Mouse   262 AVKEFDSISRLDQWLTTMLLRIKKSIQGDGEGDGDLK 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alphaSnap	NP_524180.1	SNAP	7..284	CDD:276937	176/276 (64%)
		SNAP	7..284	CDD:291599	176/276 (64%)
		TPR repeat	35..72	CDD:276937	22/36 (61%)
		TPR repeat	76..112	CDD:276937	20/35 (57%)
		TPR repeat	115..152	CDD:276937	21/36 (58%)
		TPR repeat	156..192	CDD:276937	26/35 (74%)
Napb	NP_062606.1	SNAP	9..287	CDD:276937	177/277 (64%)
		TPR repeat	37..74	CDD:276937	22/36 (61%)
		TPR repeat	78..114	CDD:276937	20/35 (57%)
		TPR repeat	117..154	CDD:276937	21/36 (58%)
		TPR repeat	158..194	CDD:276937	26/35 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849669
Domainoid	1	1.000	376	1.000	Domainoid score	I859
eggNOG	1	0.900	-	-		E1_KOG1586
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	379	1.000	Inparanoid score	I2048
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53796
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001605
OrthoInspector	1	1.000	-	-		otm44336
orthoMCL	1	0.900	-	-		OOG6_101315
Panther	1	1.100	-	-	O	PTHR13768
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1307
SonicParanoid	1	1.000	-	-		X1012
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790