Protein Alignment polo and Plk2

DIOPT Version :9

• Sequence 1: NP_001014592.1
• Gene: polo / 40232
• FlyBaseID: FBgn0003124
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_114009.1
• Gene: Plk2 / 83722
• RGDID: 620760
• Length: 682
• Species: Rattus norvegicus
• Alignment Length: 619
• Identity: 223/619 - (36%)
• Similarity: 351/619 - (56%)
• Gaps: 69/619 - (11%)

  Fly    16 LVDINQRKTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSL 80
            :||....|.|.|.:..||||||||||:.|:..:.|:|.||:....:.|.:|:||..:||.:||.|
  Rat    70 IVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRIL 134

  Fly    81 NHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQIIQGVKYLHDNRII 145
            :|.::|:|::||||.:||||:||.|.:|||..:.|.||.:||.|.|||:.||:.|:||||:..|:
  Rat   135 HHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEIL 199

  Fly   146 HRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVDIWSIG 210
            ||||||||.|:|:.:.:|:||||||.|:|....|::|:||||||::||:|.|:||..|.|||::|
  Rat   200 HRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALG 264

  Fly   211 CVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIGQLLNFE 275
            |||||:|:|:|||||..||:||..|::..|.:||.|..||..::.:||..|||.||::..::..:
  Rat   265 CVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHD 329

  Fly   276 FLKGSKVPMFLPSSCLTMAPRIGSNDTIEDSMHRKPLMEMNGIRPDDTRLESTFLKANLHD---- 336
            |......|..|.|||....|....:...: :..:|....:.|.:.|..|...|..|.:..|
  Rat   330 FFLQGFTPDRLSSSCCHTVPDFHLSSPAK-NFFKKAAAALFGGKKDKARYNDTHNKVSKEDEDIY 393

  Fly   337 ---------AITASAQVCRHSEDYRSDIESLYQQLTNLINGKPR-------ILQGNLG------- 378
                     :||......|..|:.:....:..:..|:.:..|.:       |::|.||
  Rat   394 KLRHDLKKTSITQQPSKHRTDEELQPPPTTFAKSGTSAVENKQQIGDAIRMIVRGTLGSCSSSSE 458

  Fly   379 --DENT-----DPAAQPL----------------------FWISKWVDYSDKYGFGYQLCDEGIG 414
              :::|     |..|:.|                      .|::||||||:||||||||.|..:|
  Rat   459 CLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVG 523

  Fly   415 VMFNDTTKLILLPNQINVHFIDKDGKETYMTTTDYCKSLDKKMKLLSYFKRYMIEHLVKAGANNV 479
            |:||:...:.|||::..||:..:.|:.:....||..:....::.:|.||..||.|:|:..|
  Rat   524 VLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGG---- 584

  Fly   480 NIESDQISRMPHLH--SWFRTTCAVVMHLTNGSVQLNF-SDHMKLILCPRMS--AITYMDQEKNF 539
            ::.|....|.|.|:  .|.::..|::|...:|:.|:|| .||.|:|:|.:..  .:||:::::..
  Rat   585 DLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICNQNEEYLLTYINEDRIS 649

  Fly   540 RTYRFSTIVENGVSKDLYQKIRYAQEKLRKMLEK 573
            .|:|.:|::.:|.|.:|..::.||   |..:|::
  Rat   650 TTFRLTTLLMSGCSLELKHRMEYA---LNMLLQR 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
polo	NP_001014592.1	STKc_PLK	23..277	CDD:271001	129/253 (51%)
		POLO_box_1	388..475	CDD:240561	36/108 (33%)
		POLO_box_2	490..570	CDD:240560	25/84 (30%)
Plk2	NP_114009.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..67
		STKc_PLK2	77..331	CDD:271090	129/253 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	402..430		4/27 (15%)
		POLO_box_1	500..585	CDD:240561	36/88 (41%)
		POLO_box_2	598..679	CDD:240560	23/83 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0575
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D373288at33208
OrthoFinder	1	1.000	-	-		FOG0000754
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100759
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X638
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720