Protein Alignment polo and Plk3

DIOPT Version :9

• Sequence 1: NP_001014592.1
• Gene: polo / 40232
• FlyBaseID: FBgn0003124
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_071523.1
• Gene: Plk3 / 58936
• RGDID: 62039
• Length: 647
• Species: Rattus norvegicus
• Alignment Length: 607
• Identity: 236/607 - (38%)
• Similarity: 343/607 - (56%)
• Gaps: 62/607 - (10%)

  Fly    13 PD--RLV-DINQRKTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEI 74
            ||  ||: |....:||.:.|..||||||:|||..|.||...:|.|::.:..:.|.:|:||...||
  Rat    47 PDASRLITDPRSGRTYIKGRLLGKGGFARCYEATDTETSIAYAVKVIPQSRVAKPHQREKIINEI 111

  Fly    75 TIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQIIQGVKYL 139
            .:||.|.|.:||:|.::|||:.||||.||||.::|:..:.|.|.::.|.|.|||:.||:.|:|||
  Rat   112 ELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYL 176

  Fly   140 HDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEV 204
            |...|:||||||||.|:.|.:.:|:||||||.|:|...:||||:||||||:|||:|.::||..|.
  Rat   177 HQRGILHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEA 241

  Fly   205 DIWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIG 269
            |:||:||||||||.|.|||||..||:||..||:..|.:|:.|..||..::.|:|:.:|..||:|.
  Rat   242 DVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIE 306

  Fly   270 QLLNFEFLKGSKVPMFLP-SSCLTMAPRIGSNDTIEDSMHRKPLMEMNGIRPDDTR--------- 324
            |:|..:|......|..|| |||:|:......|..  .|:..|....:.|.|....:
  Rat   307 QILRHDFFTKGYTPDRLPVSSCVTVPDLTPPNPA--RSLFAKVTKSLFGRRKSKNKNHSEEQDNV 369

  Fly   325 --LESTFLKANL-H-----DAITASA-----QVCRHSED-------------------YRSDIES 357
              |.|..::.:: |     :|..|||     .|...:||                   ..:.:||
  Rat   370 SCLVSGLMRTSIGHPDVRPEAPAASALAPVSLVETAAEDSSPRGTLASSGDGFEEGLTVTTVVES 434

  Fly   358 LYQQLTNLINGKPRILQGNLGDENTDPAAQ--PLFWISKWVDYSDKYGFGYQLCDEGIGVMFNDT 420
            ....|.|.:...|.      .::|..|.||  ||.|:|||||||:|:||||||....:.|:|||.
  Rat   435 ALCALRNCVAFMPP------AEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDG 493

  Fly   421 TKLILLPNQINVHFIDKDGKETYMTTTDYCKSLDKKMKLLSYFKRYMIEHLVKAGANNVNIESDQ 485
            |.:.|..|:..||:.....|....:.....::|..::.:|.||..||.:||:| |.:..::|..:
  Rat   494 THMALSANRKTVHYNPTSTKHFSFSVGSVPRALQPQLGILRYFASYMEQHLMK-GGDLPSVEEVE 557

  Fly   486 ISRMPHLHSWFRTTCAVVMHLTNGSVQLNF-SDHMKLILC---PRMSAITYMDQEKNFRTYRFST 546
            :...|.|..|.:|..|::|..::|:||:|| .||.||||.   |.:  :|::.:.::..||..|.
  Rat   558 VPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLL--VTFVARNRSACTYLASH 620

  Fly   547 IVENGVSKDLYQKIRYAQEKLR 568
            :.:.|.|.||.|::|||...||
  Rat   621 LRQLGCSPDLRQRLRYALRLLR 642

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
polo	NP_001014592.1	STKc_PLK	23..277	CDD:271001	129/253 (51%)
		POLO_box_1	388..475	CDD:240561	36/86 (42%)
		POLO_box_2	490..570	CDD:240560	32/83 (39%)
Plk3	NP_071523.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		4/8 (50%)
		STKc_PLK3	60..314	CDD:271091	129/253 (51%)
		S_TKc	62..314	CDD:214567	128/251 (51%)
		POLO_box_1	461..549	CDD:240561	37/88 (42%)
		POLO_box_2	562..629	CDD:240560	24/68 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0575
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D373288at33208
OrthoFinder	1	1.000	-	-		FOG0000754
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100759
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X638
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720