Protein Alignment polo and plk3

DIOPT Version :10

• Sequence 1: NP_524179.2
• Gene: polo / 40232
• FlyBaseID: FBgn0003124
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_001006766.1
• Gene: plk3 / 448451
• XenbaseID: XB-GENE-5860546
• Length: 661
• Species: Xenopus tropicalis
• Alignment Length: 630
• Identity: 229/630 - (36%)
• Similarity: 351/630 - (55%)
• Gaps: 67/630 - (10%)

  Fly     4 KPE-DKSTDIPDRLV-DINQRKTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQ 66
            ||| .:|...|.:|: |....|.|.:.|..||||||:|||:.:|.|:..:|.|::....:.|.:|
 Frog    37 KPEPQRSPQQPCKLITDPLTGKAYTKGRLLGKGGFARCYEMTEVATNKTYAVKVIPHSRVAKPHQ 101

  Fly    67 KEKTAQEITIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFECRYYIYQ 131
            :||...||.:||.|:|.::|||.::||||:||||.||:|.::|:..:.|.|.::.|.|.||::.|
 Frog   102 REKIVNEIDLHRELHHKHVVKFSHHFEDSENIYIFLEICSRKSLAHIWKARHTLLEPEVRYFLKQ 166

  Fly   132 IIQGVKYLHDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILT 196
            ||.|:||||...|:||||||||.|:|:.:.:|:||||||.|:|...:||||:||||||:|||:|.
 Frog   167 IISGLKYLHLKGILHRDLKLGNFFINESMELKVGDFGLAARLEPPEQRKKTICGTPNYLAPEVLY 231

  Fly   197 KKGHSFEVDIWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPN 261
            ::||..|.||||:||||||||.|.|||||..||:||..||:.:|.:|:.|...|..:::.:|:..
 Frog   232 RQGHGPESDIWSLGCVMYTLLCGTPPFETSDLKETYRCIKQVKYTLPACLSSAAKHLLMGILKRT 296

  Fly   262 PESRPAIGQLLNFEFLKGSKVPMFLPSSCLTMAPRIGSNDTIEDSMHRKPLMEMNGIRPDDTRLE 326
            |..|..:.|:|..||......|..||.|...|.|.:...:..: |:..|....:.|.....|:..
 Frog   297 PGERLTLDQILEHEFFTKGYTPDKLPPSSCVMVPDLHPPNPAK-SLFTKVAKSLFGKTKSKTKKS 360

  Fly   327 STFLKANLHDAIT--ASAQVCR-----------------HSEDYRSDIESLYQQLTNLINGK--P 370
            .|..|.::...:|  ....:||                 |:....|   |....||...:||  .
 Frog   361 PTEEKDDISKIVTGLVKTSICRQLSYKTVDGNEVAPVTSHAVSANS---SPVDTLTEEASGKSVS 422

  Fly   371 RILQGNL---------------------------------GDENTDPAAQP--LFWISKWVDYSD 400
            |.::|:|                                 .:.|....|:|  ..|:|||||||:
 Frog   423 RSIRGSLVSSSDAFEDCVTASGVIETALAVLKDSLSSMPAVEGNPTSLAKPEHFVWVSKWVDYSN 487

  Fly   401 KYGFGYQLCDEGIGVMFNDTTKLILLPNQINVHFIDKDGKETYMTTTDYCKSLDKKMKLLSYFKR 465
            ||||||||.:..|||:||..|.::|..::.:||:...:.:.....|:...:.|..:|.:|.||..
 Frog   488 KYGFGYQLSNRSIGVLFNSGTHMVLPAHRRHVHYNLTNSRHFVFPTSAVPEQLQGQMSILQYFAT 552

  Fly   466 YMIEHLVKAGANNVNIESDQISRMPHLHSWFRTTCAVVMHLTNGSVQLNF-SDHMKLILCPRMSA 529
            ||.::|:|.|....:.|..|...:  |..|.:|..|::|..:||::|:|| :||.|:|||....|
 Frog   553 YMEKNLMKGGDLPCHEEGSQTPLL--LLQWVKTEHALLMLFSNGTLQVNFYNDHTKIILCKPQDA 615

  Fly   530 --ITYMDQEKNFRTYRFSTIVENGVSKDLYQKIRYAQEKLRKMLE 572
              :||:::::|.:|:..:|:.:.|.|.::|.::||..:.|::..|
 Frog   616 YLLTYINRDRNSQTFLLNTLTQTGCSSEMYHRLRYTVKLLQQKAE 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
polo	NP_524179.2	STKc_PLK	23..277	CDD:271001	126/253 (50%)
		POLO_box_1	388..475	CDD:240561	36/88 (41%)
		POLO_box_2	490..570	CDD:240560	28/82 (34%)
plk3	NP_001006766.1	STKc_PLK3	58..312	CDD:271091	126/253 (50%)
		POLO_box_1	477..563	CDD:240561	35/85 (41%)
		POLO_box_2	577..658	CDD:240560	28/80 (35%)