DRSC/TRiP Functional Genomics Resources

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Protein Alignment polo and plk1

DIOPT Version :9

Sequence 1:NP_001014592.1 Gene:polo / 40232 FlyBaseID:FBgn0003124 Length:576 Species:Drosophila melanogaster
Sequence 2:NP_998844.1 Gene:plk1 / 407937 XenbaseID:XB-GENE-941540 Length:598 Species:Xenopus tropicalis


Alignment Length:587 Identity:301/587 - (51%)
Similarity:406/587 - (69%) Gaps:31/587 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 AAKP------EDKSTDIPDRLVDINQRKTYKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKL 60
            |.||      .....:||:.|||...|:.|.|.||.|||||||||||.|:|:.:|||||||.|.:
 Frog    15 AGKPPGIPGSSSSVKEIPEILVDPRTRRRYLRGRFLGKGGFAKCYEITDLESREVFAGKIVPKTM 79

  Fly    61 MIKHNQKEKTAQEITIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFEC 125
            ::|.:||:|...||.|.|||:|.::|.||.:|||:..:|:|||||::||::|||||||::||.|.
 Frog    80 LLKPHQKDKMTMEIAIQRSLDHRHVVGFHGFFEDNDFVYVVLELCRRRSLLELHKRRKAVTEPEA 144

  Fly   126 RYYIYQIIQGVKYLHDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYI 190
            |||:.|.|.|.:|||.||:||||||||||||||.:.||||||||||::||:||||||||||||||
 Frog   145 RYYLKQTILGCQYLHSNRVIHRDLKLGNLFLNDEMEVKIGDFGLATKVEYDGERKKTLCGTPNYI 209

  Fly   191 APEILTKKGHSFEVDIWSIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVI 255
            |||:|.|||||||||||||||:|||||||:|||||..||:||.:|||.||.||.::...|..::.
 Frog   210 APEVLGKKGHSFEVDIWSIGCIMYTLLVGKPPFETSCLKETYMRIKKNEYSVPKHINPMATALIQ 274

  Fly   256 AMLQPNPESRPAIGQLLNFEFLKGSKVPMFLPSSCLTMAPRIG-SNDTIEDSMHRKPLMEMNGIR 319
            .||:..|.|||.|..|||.||.....:|..||::|||:.||.. :..||:.|: ||||..:|  :
 Frog   275 KMLRSEPTSRPTIDDLLNDEFFTTGYIPSRLPTTCLTVPPRFSIAPSTIDQSL-RKPLTAIN--K 336

  Fly   320 PDDTRLESTFLKANLHDAITASAQVCRHSED------YRSDIESLYQQLTNLINGKPRILQGNLG 378
            ..|:.|..       ..::.|..:..:..|.      |.|:   :.||||.:...||........
 Frog   337 GQDSPLVE-------KQSVPAKEEEMQQPESTEPADCYLSE---MLQQLTCVNAVKPSERAVIRQ 391

  Fly   379 DENTDPAAQPLFWISKWVDYSDKYGFGYQLCDEGIGVMFNDTTKLILLPNQINVHFIDKDGKETY 443
            :|..|||:.|:||:|||||||||||.||||||..:||:|||:|:||:..:..::.:|:::..|:|
 Frog   392 EEAEDPASVPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLIMYNDGDSLQYIERNNSESY 456

  Fly   444 MTTTDYCKSLDKKMKLLSYFKRYMIEHLVKAGANNVNIESDQISRMPHLHSWFRTTCAVVMHLTN 508
            :....|..:|.||:.||.||:.||.|||:|||||....|.|:::|:|.|.:||||..|:::||:|
 Frog   457 LNVRSYPAALTKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPFLRTWFRTRSAIILHLSN 521

  Fly   509 GSVQLN-FSDHMKLILCPRMSAITYMDQEKNFRTYRFSTIVENGVSKDLYQKIRYAQEKLRKMLE 572
            |:||:| |.||.|:||||.|:|::|:|:::.|.||:.|.|.|.|..|:|..::|||    |.|:|
 Frog   522 GTVQINFFQDHTKIILCPLMAAVSYIDEKREFHTYKLSLIQEFGCCKELASRLRYA----RTMVE 582

  Fly   573 KM 574
            |:
 Frog   583 KL 584

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
poloNP_001014592.1 STKc_PLK 23..277 CDD:271001 165/253 (65%)
POLO_box_1 388..475 CDD:240561 45/86 (52%)
POLO_box_2 490..570 CDD:240560 39/80 (49%)
plk1NP_998844.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 3/10 (30%)
STKc_PLK1 36..300 CDD:271089 169/263 (64%)
Activation loop. /evidence=ECO:0000250 185..212 23/26 (88%)
D-box that targets the protein for proteasomal degradation in anaphase. /evidence=ECO:0000250 328..331 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 336..360 3/30 (10%)
POLO_box_1 401..488 CDD:240561 45/86 (52%)
Linker. /evidence=ECO:0000250 487..501 6/13 (46%)
POLO_box_2 503..584 CDD:240560 41/84 (49%)
Important for interaction with phosphorylated proteins. /evidence=ECO:0000250 532..534 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 354 1.000 Domainoid score I996
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3690
Inparanoid 1 1.050 597 1.000 Inparanoid score I950
OMA 1 1.010 - - QHG54080
OrthoDB 1 1.010 - - D373288at33208
OrthoFinder 1 1.000 - - FOG0000754
OrthoInspector 1 1.000 - - oto103458
Panther 1 1.100 - - LDO PTHR24345
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R930
SonicParanoid 1 1.000 - - X638
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1212.110

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