Protein Alignment polo and SAK

DIOPT Version :10

• Sequence 1: NP_524179.2
• Gene: polo / 40232
• FlyBaseID: FBgn0003124
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_649324.1
• Gene: SAK / 40384
• FlyBaseID: FBgn0026371
• Length: 769
• Species: Drosophila melanogaster
• Alignment Length: 505
• Identity: 143/505 - (28%)
• Similarity: 228/505 - (45%)
• Gaps: 114/505 - (22%)

  Fly    25 YKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSLNHPNIVKFH 89
            |:.....||||||..|:...:.|....|.|::.|||:.......:..||:.||..|.||::::.:
  Fly    14 YEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVLQLY 78

  Fly    90 NYFEDSQNIYIVLELCKKRSMMELHKRRKSI----TEFECRYYIYQIIQGVKYLHDNRIIHRDLK 150
            .:|:|:..:|:||||....   |||:....|    ||.|....:.|::.|:.|||.:.|:|||:.
  Fly    79 TFFQDANYVYLVLELAHNG---ELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHRDIS 140

  Fly   151 LGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVDIWSIGCVMYT 215
            |.||.|:..:||||.||||||:::...||..|:|||||||:||::::..|....|:||:||::||
  Fly   141 LSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYT 205

  Fly   216 LLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIGQLLNFEF-LKG 279
            ||||:|||||..::.|.:|:...||.:|::|...|.|::..:|:..|..|..:..:|...| ||.
  Fly   206 LLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKC 270

  Fly   280 SKVPMFLPSSCLTMAPRIGSNDTIEDSMHRKPLMEMNGIRPDDTRLESTFLKANLHDAITASAQV 344
            |......|.:....:..:.|.|              :||                   ||.::..
  Fly   271 SNGGHSAPGALNVFSQSMESGD--------------SGI-------------------ITFASSD 302

  Fly   345 CRHSEDYRSDIESLYQQLTNLINGKPRILQGNLGDENTDPAAQPLFWISKWVDYSDKYGFGYQLC 409
            .|:|:..|| :|                   |.|.:...|..:..|   |.|.:...|
  Fly   303 SRNSQQIRS-VE-------------------NSGPQQVLPQIREEF---KQVHHKLPY------- 337

  Fly   410 DEGIGVMFNDTTKLILLPNQINVHFIDKDGKETYMTTTDYCKSLDKKMKLLSYFKRYMIEHLVKA 474
             |..| :|...:..:..||....           ..::.:|                     ::|
  Fly   338 -EQTG-LFGQASTGLAEPNWPGA-----------AKSSAFC---------------------MEA 368

  Fly   475 G----ANNVNIESDQISRMP-----HLHSWFRTTCAVVMHLTNGSVQLNF 515
            |    :...:::.|:||..|     .|.:.::|..|::..|.||.|.|.|
  Fly   369 GNVPNSKQASLKEDRISVPPLNTKRLLPTRYKTKNAIMSILRNGEVVLEF 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
polo	NP_524179.2	STKc_PLK	23..277	CDD:271001	100/256 (39%)
		POLO_box_1	388..475	CDD:240561	10/86 (12%)
		POLO_box_2	490..570	CDD:240560	10/31 (32%)
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	99/255 (39%)
		POLO_box_Plk4_1	382..497	CDD:240557	13/37 (35%)
		POLO_box_Plk4_2	498..596	CDD:240558
		POLO_box_Plk4_3	657..738	CDD:240559